Title:
SURGICAL SEALANT
Document Type and Number:
WIPO Patent Application WO/2016/117569
Kind Code:
A1
Abstract:
In the present invention, a surgical sealant comprising a first agent containing a hydrophobized gelatin derived from a cold-water fish and a second agent containing water-soluble molecules for crosslinking is characterized in that the water-soluble molecules for crosslinking are at least one type selected from the group consisting of polybasic acids and acid anhydrides having two or more active ester groups and aldehyde compounds having two or more aldehyde groups, the hydrophobized gelatin derived from a cold-water fish is gelatin where at least a portion of the amino groups in the side chains of the gelatin derived from a cold-water fish is substituted by hydrophobic groups, and the hydrophobic groups are C8-18 linear-chain aliphatic groups having a substitution rate (number of moles of hydrophobic groups/(total number of moles of hydrophobic groups and reactive amino groups in the gelatin) x 100) is 3 to 20 mol%.
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Inventors:
TAGUCHI TETSUSHI (JP)
Application Number:
PCT/JP2016/051463
Publication Date:
July 28, 2016
Filing Date:
January 19, 2016
Export Citation:
Assignee:
NAT INST FOR MATERIALS SCIENCE (JP)
International Classes:
A61L24/00
Domestic Patent References:
| WO2014112208A1 | 2014-07-24 | |||
| WO2015076252A1 | 2015-05-28 | |||
| WO2012046717A1 | 2012-04-12 | |||
| WO2012046759A1 | 2012-04-12 |
Foreign References:
| JP2014100420A | 2014-06-05 | |||
| JP2014180253A | 2014-09-29 |
Other References:
RYO MIZUTA ET AL.: "Shitsujun Kekkan Soshiki ni Taisuru Sosuika Gelatin no Sealing Koka", POLYMER PREPRINTS, vol. 63, no. 1, 2014, Japan, pages 3627 - 3628, XP009504741
RYO MIZUTA ET AL.: "Shitsujun Kankyo de Kekkan Soshiki Secchakusei o Shimesu Seitai Shinwasei Sealant no Sosei", POLYMER PREPRINTS, vol. 64, no. 2, 25 August 2015 (2015-08-25), pages 3V09, XP009504743
TETSUSHI TAGUCHI ET AL.: "Tokushu Takino-Kodoka suru Needs ni Kotaeru Secchaku Gijutsu no Saishin Tenkai [Kaisetsu 5] Seitai Shinwasei no Takai Iryo-yo Secchakuzai no Kaihatsu Doko", KOGYO ZAIRYO, vol. 63, no. 6, 1 June 2015 (2015-06-01), pages 44 - 50, XP009504746
YOSHIZAWA, K. ET AL.: "Enhanced Bonding Strength of Hydrophobically Modified Gelatin Films on Wet Blood Vessels", INT. J. MOL. SCI., vol. 15, no. 2, 2014, pages 2142 - 2156, XP055466297
See also references of EP 3248622A4
RYO MIZUTA ET AL.: "Shitsujun Kankyo de Kekkan Soshiki Secchakusei o Shimesu Seitai Shinwasei Sealant no Sosei", POLYMER PREPRINTS, vol. 64, no. 2, 25 August 2015 (2015-08-25), pages 3V09, XP009504743
TETSUSHI TAGUCHI ET AL.: "Tokushu Takino-Kodoka suru Needs ni Kotaeru Secchaku Gijutsu no Saishin Tenkai [Kaisetsu 5] Seitai Shinwasei no Takai Iryo-yo Secchakuzai no Kaihatsu Doko", KOGYO ZAIRYO, vol. 63, no. 6, 1 June 2015 (2015-06-01), pages 44 - 50, XP009504746
YOSHIZAWA, K. ET AL.: "Enhanced Bonding Strength of Hydrophobically Modified Gelatin Films on Wet Blood Vessels", INT. J. MOL. SCI., vol. 15, no. 2, 2014, pages 2142 - 2156, XP055466297
See also references of EP 3248622A4
Attorney, Agent or Firm:
NISHIZAWA TOSHIO (JP)
Toshio Nishizawa (JP)
Toshio Nishizawa (JP)
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