SUSTAINED DRUG RELEASE SHEET FOR TREATING NERVE DAMAGE

Title:

SUSTAINED DRUG RELEASE SHEET FOR TREATING NERVE DAMAGE

Document Type and Number:

WIPO Patent Application WO/2017/154822

Kind Code:

A1

Abstract:

Provided is a sustained release sheet that includes a drug for treating nerve damage, wherein the sheet is applied to a nerve damage site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve damage site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve damage is a sheet comprising a nonwoven fabric that is formed from nanofibers which include a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve damage site to promote nerve regeneration.

Inventors:

TANAKA HIROYUKI (JP)
OKADA KIYOSHI (JP)
YOSHIKAWA HIDEKI (JP)
SUZUKI KOUJI (JP)
EBARA MITSUHIRO (JP)

Application Number:

PCT/JP2017/008730

Publication Date:

September 14, 2017

Filing Date:

March 06, 2017

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV OSAKA (JP)
NAT INST FOR MATERIALS SCIENCE (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)

International Classes:

A61K9/70; A61K31/714; A61K35/36; A61K38/18; A61K45/00; A61K47/34; A61K47/36; A61P25/00; A61P25/02

Domestic Patent References:

WO2011162317A1	2011-12-29
WO2014109379A1	2014-07-17
WO2013013038A2	2013-01-24

Foreign References:

JP2014522918A	2014-09-08
JP2007236551A	2007-09-20
JPS60255726A	1985-12-17
JP2014177490A	2014-09-25
JP2007529508A	2007-10-25
JP2011530661A	2011-12-22

Other References: