Title:
SUSTAINED-RELEASE BUPRENORPHINE FORMULATIONS BACKGROUND OF INVENTION
Document Type and Number:
WIPO Patent Application WO/2018/050043
Kind Code:
A1
Abstract:
An injectable pharmaceutical composition includes a solution of 3-acyl-buprenorphine, or a pharmaceutically acceptable salt thereof, in a biocompatible organic solvent, wherein the injectable pharmaceutical composition exhibits a steady release profile lasting over one week when injected into a patient. The acyl group is an alkylcarbonyl group, and an alkyl portion of the alkylcarbonyl group is a straight-chain, branched-chain, having 1-20 carbon atoms. The biocompatible organic solvent is N-methyl-2-pyrrolidone, ethyl acetate, ethanol, butanol, 2-butanol, isobutanol, ispropanol, glycerin, benzyl benzoate, dimethyl sulfoxide, N, N-dimethylacetamide, propylene glycol, dimethyl glycol, benzyl alcohol, or a combination of two or more thereof.
Inventors:
LIN TONG-HO (CN)
WEN YUNG-SHUN (CN)
LIANG JUI-WEI (CN)
WEN YUNG-SHUN (CN)
LIANG JUI-WEI (CN)
Application Number:
PCT/CN2017/101327
Publication Date:
March 22, 2018
Filing Date:
September 12, 2017
Export Citation:
Assignee:
ALAR PHARMACEUTICALS INC (CN)
International Classes:
A61K9/08; A61K31/485; A61K47/10; A61K47/22; A61P25/04; A61P25/36
Domestic Patent References:
| WO2015136253A1 | 2015-09-17 | |||
| WO2011154724A2 | 2011-12-15 | |||
| WO2011154725A2 | 2011-12-15 | |||
| WO2015136253A1 | 2015-09-17 |
Foreign References:
| CN1500786A | 2004-06-02 | |||
| TW201625250A | 2016-07-16 | |||
| CN103079544A | 2013-05-01 | |||
| US7084150B2 | 2006-08-01 | |||
| EP1422230A1 | 2004-05-26 | |||
| US7964610B2 | 2011-06-21 | |||
| US20130190341A1 | 2013-07-25 | |||
| US20030152638A1 | 2003-08-14 | |||
| US20140271869A1 | 2014-09-18 | |||
| US20120308614A1 | 2012-12-06 |
Other References:
PHARM. RES, vol. 12, 1995, pages 1526 - 1529
BIOL. PHARM. BULL., vol. 19, 1996, pages 263 - 267
PHARM. RES., vol. 13, 1996, pages 1519 - 1523
BIOL. PHARM. BULL., vol. 19, 1996, pages 263 - 267
PHARM. RES., vol. 13, 1996, pages 1519 - 1523
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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