Title:
SUSTAINED-RELEASE DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/130758
Kind Code:
A1
Abstract:
The present invention provides a sustained-release drug delivery system for oral administration, and a preparation method therefor. According to the present invention, a drug for treating oral diseases is loaded on a porous material, and is combined with a medical oral material to prepare a special sustained-release drug delivery module, and the module is placed at the site of administration in the oral cavity to slowly and stably release the drug over a long period of time. The present invention effectively solves the problems in conventional treatments that administration is difficult, administration is not timely, and long treatment periods, poor treatment effects and oral discomfort of a patient due to difficulty in maintaining an effective drug concentration at an affected part. The method can be used in an efficient, long-term, stable and convenient oral disease treatment scheme.
Inventors:
YU JIHONG (CN)
TANG KANGJIAN (CN)
HENG XUAN (CN)
TANG KANGJIAN (CN)
HENG XUAN (CN)
Application Number:
PCT/CN2022/118361
Publication Date:
July 13, 2023
Filing Date:
September 13, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K9/00; A61K31/65; A61K45/00; A61K47/02; A61K47/32; A61P1/02
Foreign References:
| CN114452246A | 2022-05-10 | |||
| CN103655207A | 2014-03-26 | |||
| KR20180087204A | 2018-08-01 | |||
| CN101703449A | 2010-05-12 | |||
| CN101703450A | 2010-05-12 |
Other References:
ZHANG, J. F. ET AL.: "Antibacterial dental composites with chlorhexidine and mesoporous silica.", JOURNAL OF DENTAL RESEARCH, vol. 93, no. 12, 15 October 2014 (2014-10-15), pages 1283 - 1289, XP055585659, ISSN: 0022-0345, DOI: 10.1177/0022034514555143
PIETRELLA DONATELLA, MARMOTTINI FABIO, PADELETTI GIUSEPPINA, MONTESPERELLI GIAMPIERO, KACIULIS SAULIUS, VICI EMANUELA, CERRI LUCIA: "Resin-Based Materials with Chlorhexidine-Loaded MCM-41: Surface Characteristics, Drug Release, and Antibiofilm Activity", ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 4, no. 12, 10 December 2018 (2018-12-10), pages 4144 - 4153, XP093076904, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b00612
PIETRELLA DONATELLA, MARMOTTINI FABIO, PADELETTI GIUSEPPINA, MONTESPERELLI GIAMPIERO, KACIULIS SAULIUS, VICI EMANUELA, CERRI LUCIA: "Resin-Based Materials with Chlorhexidine-Loaded MCM-41: Surface Characteristics, Drug Release, and Antibiofilm Activity", ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 4, no. 12, 10 December 2018 (2018-12-10), pages 4144 - 4153, XP093076904, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b00612
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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