Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
SWEET POTATO SITOSTEROL GLYCOSIDE UNSATURATED FATTY ACID ESTER, EXTRACT, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/011010
Kind Code:
A1
Abstract:
The present invention relates to the field of medicinal chemistry, and specifically to a sweet potato sitosterol glycoside unsaturated fatty acid, an extract, a preparation method therefor, and an application thereof. Sweet potato sitosterol glycoside linolenic acid ester has a significant effect on inhibiting the growth of tumor cells. In the case of an administration concentration of 10 mg/L, the inhibition rate of a sweet potato sitosterol glycoside linolenic acid ester monomer of the present invention on MCF-7 cells is 92%, the inhibition rate of a sweet potato sitosterol glycoside linoleic acid ester monomer on MCF-7 cells is 65%, and the inhibition rate of a sweet potato sitosterol glycoside monomer on MCF-7 cells is 55%; in the case of an administration concentration of 1 mg/L, the inhibition rate of a contrastive sweet potato sitosterol glycoside linolenic acid ester monomer on MCF-7 cells is 45%, the inhibition rate of a sweet potato sitosterol glycoside linoleic acid ester monomer on MCF-7 cells is 15%, and the inhibition rate of a contrastive drug, i.e., a sweet potato sitosterol glycoside monomer on MCF-7 cells is 10%.

Inventors:
YE, Xiaoli (No.2, Tiansheng Road Beibei Distric, Chongqing 5, 400715, CN)
LI, Xuegang (No.2, Tiansheng Road Beibei District, Chongqing 5, 400715, CN)
Li, Yanlin (No.2, Tiansheng Road Beibei District, Chongqing 5, 400715, CN)
LI, Yasong (No 2, Tiansheng Road Beibei District, Chongqing 5, 400715, CN)
Application Number:
CN2018/081594
Publication Date:
January 17, 2019
Filing Date:
April 02, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SOUTHWEST UNIVERSITY (No.2, Tiansheng Road Beibei District, Chongqing 5, 400715, CN)
International Classes:
C07J17/00; A23L33/11; A61K36/39; A61P35/00
Domestic Patent References:
WO2002079219A22002-10-10
Other References:
GREC A, MARINA DELLA ET AL.: "Stigmasterols from Typha Latifolia", JOURNAL OF NATURAL PRODUCTS, vol. 53, no. 6, 31 December 1990 (1990-12-31), pages 1430 - 1435, XP001128730
LEE, WON BIN ET AL.: "Phytochemical Constituents of Cirsium Setidens Nakai and Their Cytotoxicity against Human Cancer Cell Lines", ARCHIVES OF PHARMACAL RESEARCH, vol. 25, no. 5, 31 December 2002 (2002-12-31), pages 628 - 635, XP053006917
PULLELA, SRINIVAS V . ET AL.: "New Acylated Clionasterol Glycosides from Valeriana Officinalis", PLANTA MEDICA, vol. 71, no. 10, 31 December 2005 (2005-12-31), pages 960 - 961, XP055570126
LEOON, ALEJANDRA ET AL.: "Phthalides and Other Constituents from Ligusticum Porteri; Sedative and Spasmolytic Activities of Some Natural Products and Derivatives", NATURAL PRODUCT RESEARCH., vol. 25, no. 13, August 2011 (2011-08-01), pages 1234 - 1242, XP055570127
KHAN, SOHAIL ET AL.: "Ailanthus Altissima (Miller) Swingle Fruit-new Acyl 0-sitosteryl Glucoside and in Vitro Pharmacological Evaluation", NATURAL PRODUCT RESEARCH, vol. 30, no. 23, 31 December 2016 (2016-12-31), pages 2629 - 2636, XP055570130
CHENG, KEWEI ET AL.: "Physiological Function Studies on Sweet Potato", FOOD SCIENCE AND TECHNOLOGY, 31 December 2003 (2003-12-31), pages 92 - 94
HOU, LIXIA ET AL.: "Comparative Study on Different Extraction Methods of Proteins in Sweet Potato Starch Production Waste Liquor", CEREALS AND OILS PROCESSING., 28 December 2010 (2010-12-28), pages 105 - 108
Attorney, Agent or Firm:
CHONGQING HUAKE PATENT ATTORNEY OFFICE (1403, Association Building NO.3, Shuanggang Road, Yuzhong District, Chongqing 0, 400000, CN)
Download PDF: