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Title:
SYK KINASE-ASSOCIATED CELL CYCLE PROTEINS, COMPOSITIONS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2001021654
Kind Code:
A3
Abstract:
The present invention is directed to polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

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Inventors:
LUO YING (US)
MANCEBO HELENA (US)
Application Number:
PCT/US2000/026338
Publication Date:
March 07, 2002
Filing Date:
September 25, 2000
Export Citation:
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Assignee:
RIGEL PHARMACEUTICALS INC (US)
LUO YING (US)
MANCEBO HELENA (US)
International Classes:
G01N33/50; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12N15/09; C12N15/12; C12P21/02; C12P21/08; C12Q1/02; C12Q1/48; G01N33/15; G01N33/566; (IPC1-7): C12N15/12; C07K14/47; C07K16/18; G01N33/50; G01N33/68
Domestic Patent References:
WO1999046289A11999-09-16
WO2000078934A22000-12-28
WO2000079267A22000-12-28
WO1994025565A11994-11-10
WO1999025829A21999-05-27
Other References:
VALERO REBECA ET AL.: "USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2", GENOMICS, vol. 62, no. 3, 15 December 1999 (1999-12-15), pages 395 - 405, XP002153277, ISSN: 0888-7543
See also references of EP 1218505A2
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