Title:
SYNBIOTICS COMBINATION FOR BRAIN IMPROVEMENT
Document Type and Number:
WIPO Patent Application WO/2014/070016
Kind Code:
A3
Abstract:
The invention relates to nutritional compositions with Bifidobacterium breve and non-digestible oligosaccharides selected from the group consisting of fructo-oligosaccharides, galacto-oligosaccharides, gluco- oligosaccharides, arabino-oligosaccharides, mannan-oligosaccharides, xylo-oligosaccharides, fuco-oligosaccharides, arabinogalacto- oligosaccharides, glucomanno-oligosaccharides, galactomanno- oligosaccharides, sialic acid comprising oligosaccharides and uronic acid oligosaccharides for use in improving cognitive or behavioral performance, cognitive or behavioral development, social interaction and/or neuroinflammation in infants or toddlers. Also claimed is the use of a nuritional compositions including Bifidobacterium breve, at least one non digestible oligosaccharide, glutamine in the form of free amino acids and/or glutamine containing dipeptide and/or glutaime containing tripeptide and LC-PUFA in the form or arachidonic acid and/or docosahexaenoic acid. Also claimed is a kit of parts comprising a first container comprising glutamine, and a non-digestible oligosaccharide and a second container comprising Bifidobacterium breve.
Inventors:
GARSSEN JOHAN (NL)
VAN ELBURG RUURD (NL)
BARKE NANA (NL)
KRANEVELD ALETTA DESIREE (NL)
VAN ELBURG RUURD (NL)
BARKE NANA (NL)
KRANEVELD ALETTA DESIREE (NL)
Application Number:
PCT/NL2013/050785
Publication Date:
June 26, 2014
Filing Date:
November 04, 2013
Export Citation:
Assignee:
NUTRICIA NV (NL)
International Classes:
A23L1/30; A23L1/305; A23L33/00; A61K31/702; A61K35/74; A61K35/745
Domestic Patent References:
| WO2008111832A1 | 2008-09-18 | |||
| WO2008108651A1 | 2008-09-12 | |||
| WO2013105851A1 | 2013-07-18 |
Foreign References:
| US20070207132A1 | 2007-09-06 | |||
| US20120171165A1 | 2012-07-05 | |||
| US20100278781A1 | 2010-11-04 | |||
| US20030138476A1 | 2003-07-24 | |||
| US20110086809A1 | 2011-04-14 | |||
| EP2308498A1 | 2011-04-13 | |||
| EP2335502A1 | 2011-06-22 | |||
| US20080241226A1 | 2008-10-02 |
Other References:
KIN B ET AL: "Learning ability-improving compsn. - contains sialic acid-contg. oligo:saccharide", WPI/THOMSON,, vol. 1996, no. 51, 15 October 1996 (1996-10-15), XP002500689
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2005 (2005-09-01), ADESANYA OLUBUKUNOLA A ET AL: "Intestinal perforation in very low birth weight infants: growth and neurodevelopment at 1 year of age.", XP002704986, Database accession no. NLM16034475
FIELD ET AL: "A comparison of symptoms used by mothers and nurses to identify an infant with colic", INTERNATIONAL JOURNAL OF NURSING STUDIES, PERGAMON, AMSTERDAM, NL, vol. 31, no. 2, 1 April 1994 (1994-04-01), pages 201 - 215, XP022870583, ISSN: 0020-7489, [retrieved on 19940401], DOI: 10.1016/0020-7489(94)90046-9
DE KIEVIET JORRIT F ET AL: "Effects of Glutamine on Brain Development in Very Preterm Children at School Age", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, EVANSTON, IL, US, vol. 130, no. 5, 1 November 2012 (2012-11-01), pages e1121 - e1127, XP009168039, ISSN: 0031-4005
DE KIEVIET JORRIT F ET AL: "Effects of neonatal enteral glutamine supplementation on cognitive, motor and behavioural outcomes in very preterm and/or very low birth weight children at school age", BRITISH JOURNAL OF NUTRITION, CAMBRIDGE UNIV. PRESS, UK, vol. 108, no. 12, 1 December 2012 (2012-12-01), pages 2215 - 2220, XP009168040, ISSN: 0007-1145, DOI: 10.1017/S0007114512000293
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2005 (2005-09-01), ADESANYA OLUBUKUNOLA A ET AL: "Intestinal perforation in very low birth weight infants: growth and neurodevelopment at 1 year of age.", XP002704986, Database accession no. NLM16034475
FIELD ET AL: "A comparison of symptoms used by mothers and nurses to identify an infant with colic", INTERNATIONAL JOURNAL OF NURSING STUDIES, PERGAMON, AMSTERDAM, NL, vol. 31, no. 2, 1 April 1994 (1994-04-01), pages 201 - 215, XP022870583, ISSN: 0020-7489, [retrieved on 19940401], DOI: 10.1016/0020-7489(94)90046-9
DE KIEVIET JORRIT F ET AL: "Effects of Glutamine on Brain Development in Very Preterm Children at School Age", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, EVANSTON, IL, US, vol. 130, no. 5, 1 November 2012 (2012-11-01), pages e1121 - e1127, XP009168039, ISSN: 0031-4005
DE KIEVIET JORRIT F ET AL: "Effects of neonatal enteral glutamine supplementation on cognitive, motor and behavioural outcomes in very preterm and/or very low birth weight children at school age", BRITISH JOURNAL OF NUTRITION, CAMBRIDGE UNIV. PRESS, UK, vol. 108, no. 12, 1 December 2012 (2012-12-01), pages 2215 - 2220, XP009168040, ISSN: 0007-1145, DOI: 10.1017/S0007114512000293
Attorney, Agent or Firm:
NEDERLANDSCH OCTROOIBUREAU (JS The Hague, NL)
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