BIYANI MANISH RADHESHYAM (IN)
AUDDY BISWAJIT (IN)
CHAKRABARTI SHRABANA (IN)
WO 2016/203499 AMENDED CLAI MS PCT/IN2016/050189 received by the International Bureau on 09 January 2017 (09.01.2017) I Claim: 1. A synergistic beverage composition for alleviating one or more physiological parameters selected from alcohol-induced oxidative stress, hepatic stress, CNS stress, veisalgia and modulating immunology parameters, the composition comprising atleast two components selected from: (a) a saponin glycoside in a mass concentration range of 0.01 to 0.5 %; (b) an Amino-Acid derivative in a mass concentration range of 0.04 to 3.0%; and (c) a sugar alcohol in a mass concentration range of 0.5 to 3.0 %. 2. The synergistic beverage composition as claimed in claim 1, wherein the saponin glycoside comprises Glycyrrhizin (GA) or Glycyrrhizin (GA) salt, or a combination thereof. 3. The synergistic beverage composition as claimed in claim 2, wherein the Glycyrrhizin (GA) is selected from 18-P-Glycyrrhizin and 18-a-Glycyrrhizin, or a combination thereof. 4. The synergistic beverage composition as claimed in claim 2, wherein the Glycyrrhizin(GA) salt is selected from 18-a-Glycyrrhizin mono ammonium salt and 18-P-Glycyrrhizin mono ammonium salt, or a combination thereof. 5. The synergistic beverage composition as claimed in claim 2, wherein the saponin glycoside is in a mass concentration range of 0.04 to 0.5%. 6. The synergistic beverage composition as claimed in claim 3, wherein the Glycyrrhizin (GA) comprises equal parts of 18-P-Glycyrrhizin and 18-a-Glycyrrhizin. 7. The synergistic beverage composition as claimed in claim 1, wherein the Amino-Acid derivative is selected from the group consisting of an amino-acid monomer, a dipeptide, a tripeptide, an oligopeptide, a polypeptide, and a protein hydrolysate. 8. The synergistic beverage composition as claimed in claim 7, wherein the amino-acid monomer is selected from the group consisting of alanine, glutamine, arginine, ornithine, arginine pryoglutamate, asparaginine, L-Aspartic acid, D-Asparatic acid, L- Carnitine, citruline, cysteine, cystine, gamma- aminobutyric acid (GABA), glutathione, glycine, histidine, L-isoleucine, L-leucine, L-lysine, methionine, phenylalanine, L-proline, pyroglutamate, serine, threonine, tyrptophan, tyrosine, L- valine, and L-Theanine, or a combination thereof. 9. The synergistic beverage composition as claimed in claim 7, wherein the dipeptide (DP) is selected from the group consisting of L-alanyl-L-glutamine (L-Ala-L-Gln), 68 glycyl-glycine (Gly-Gly) and L-glutamyl-L-alanine (Glu-Ala), or a combination thereof. 10. The synergistic beverage composition as claimed in claim 7, wherein the oligopeptide is selected from the group consisting of Oxidised L-Glutathione, Reduced L- Glutathione and Glutathione. 11. The synergistic beverage composition as claimed in claim 7, wherein the protein hydrolysate is selected from hydrolysed casein protein and hydrolysed whey protein. 12. The synergistic beverage composition as claimed in claim 7, wherein the Amino-Acid derivative is in a mass concentration range of 0.5 to 3.0%. 13. The synergistic beverage composition as claimed in claim 1, wherein the sugar alcohol is selected from the group consisting of D-Glycerol, L-Glycerol, D-Mannitol, L-Mannitol, D-erythritol, L-erythritol, D-xylitol, or L-xylitol, L-Maltitol, D-Maltitol, L-Sorbitol, D-Sorbitol, L-Lactitol, D-Lactitol, L-Isomalt and D-Isomalt, or a mixture thereof. 14. The synergistic beverage composition as claimed in claim 13, wherein the sugar alcohol is D-Mannitol or L-Mannitol. 15. The synergistic beverage composition as claimed in claim 13, wherein the sugar alcohol is in a mass concentration range of 0.5 to 2.5%. 16. The synergistic beverage composition as claimed in claim 1, wherein the composition further comprises pH adjusting agent and flavouring agent. 17. The synergistic beverage composition as claimed in claim 16, wherein the pH adjusting agent is an organic or inorganic base/ buffer, selected from the group consisting of potassium sorbate (KS), monobasic sodium phosphate, dibasic sodium phosphate and tribasic sodium phosphate. 18. The synergistic beverage composition as claimed in claim 17, wherein the pH adjusting agent comprises potassium sorbate (KS) in a mass concentration range of 0.01 to 0.2%. 19. The synergistic beverage composition as claimed in claim 16, wherein the flavouring agent is selected from the group consisting of extracts of herbs, spices, fruit, and artificial flavour, in mass concentration range of 0.01 to 0.2%. 69 20. The synergistic beverage composition as claimed in claim 1, wherein the composition is selected from the group comprising of: a. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin,in a mass concentration of 0.04%, D- Xylitol,L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1%; b. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1%; c. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.04%, %, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 2.5%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1%; d. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.04%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 0.5%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 0.5%; e. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 0.5%; f. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 3.0%; g. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.15%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1.0%; h. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.3%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1.0%; i. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 2.5%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1.0%; j. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, 70 and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1.25%; k. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 2.0%; 1. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1.5%; m. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and casein hydrosylate protein in a mass concentration of 1.0%; n. 18-a-Glycyrrhizin or 18-P-Glycyrrhizin in a mass concentration of 0.1%, D- Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and casein hydrosylate protein in a mass concentration of 2.0%; o. 18-a-Glycyrrhizin in a mass concentration of 0.05%, 18-β- Glycyrrhizin in a mass concentration of 0.05%, D-Xylitol, L-Xylitol, D-Mannitol or L-Mannitol in a mass concentration of 1.2%, and L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration of 1.0%; p. equal parts 18a-Glycyrrhizin andl8-P-Glycyrrhizin in a combined mass concentration range of 0.04 to 0.1%, a sugar alcohol selected from the group consisting of D-Xylitol, L-Xylitol, D-Mannitol, and L-Xylitol in a mass concentration range of 0.5 to 2.5%, and a dipeptide comprising L-alanyl-L- glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration range of 0.5 to 3.0%; and q. saponin glycoside comprising 18a-Glycyrrhizin orl8-P-Glycyrrhizin, or a combination thereof, in a mass concentration range of 0.04 to 0.1%, a sugar alcohol selected from the group consisting of D-Xylitol, L-Xylitol, D-Mannitol, and L-Xylitol in a mass concentration range of 0.5 to 2.5%, and a dipeptide comprising L-alanyl-L-glutamine (L-Ala-L-Gln) or oxidised L-glutathione in a mass concentration range of 0.5 to 3.0%. 22. The synergistic beverage composition for reducing hepatic stress as claimed in claim 1 comprising (a) saponin glycoside in a mass concentration range of 0.04 to 0.3 %; (b) an Amino acid derivative in a mass concentration range of 0.5 to 2.0%; and (c) a sugar alcohol in a mass concentration range of 0.5 to 2.5 %. 23. The synergistic beverage composition for reducing CNS stress, immunology and hangover as claimed in claim 1, comprising (a) saponin glycoside is in a mass concentration range of 0.04 to 0.3 %; (b) an Amino acid derivative is in a mass 71 concentration range of 0.5 to 3.0%; and (c) a sugar alcohol is in a mass concentration range of 0.5 to 2.5 %. 24. The synergistic beverage composition as claimed in claim 22, wherein the reduction of hepatic stress is evaluated by measuring the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatise (ALP). 25. The synergistic beverage composition as claimed in claim 23, wherein the reduction of CNS stress is evaluated by measuring the levels of acetylcholine esterase (ACHe), interleukin-12 (IL-12), Brain interleukin-12 (IL-12), Monocyte chemoattractant protein -1 (MCP-1), Brain Monocyte chemoattractant protein -1 (Brain MCP-1) and water maze behavioural aspect. 26. The synergistic beverage composition as claimed in claim 23, wherein the reduction of immunology parameters is evaluated by measuring the levels of C-reactive protein (CRP), interleukin-12 (IL-12), brain interleukin-12 (Brain IL-12), Monocyte chemoattractant protein -1 (MCP-1), Brain Monocyte chemoattractant protein -1 (Brain MCP-1) and interferon gamma (IFN-Gamma). 27. The synergistic beverage composition as claimed in claim 23, wherein the reduction of veisalgia (hangover) is evaluated by measuring the levels of acetylcholine esterase (ACHe), C-reactive protein (CRP), interleukin-12 (IL-12), brain interleukin-12 (Brain IL-12), Monocyte chemoattractant protein -1 (MCP-1), brain Monocyte chemoattractant protein -1 (Brain MCP-1) and interferon gamma (IFN-Gamma). 28. The synergistic beverage composition for reducing hepatic stress as claimed in claim 1 comprising (a) Sugar Alcohol in a mass concentration range of 1.2 - 2.5% ; and (b) Amino Acid Derivative in a mass concentration range of 1.0 - 1.25%. 29. The synergistic beverage composition for reducing hepatic stress as claimed in claim 1 comprising (a) Saponin Glycoside in a mass concentration range of 0.1% and (b) Amino Acid Derivative in a mass concentration range of 1.0 - 1.25%. 30. The synergistic beverage composition as claimed in claims 28 or 29, wherein the reduction of hepatic stress is evaluated by measuring the levels of one or more parameter selected from alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatise (ALP). 31. The synergistic beverage composition for reducing CNS stress and immunology as claimed in claim 1, comprising (a) sugar alcohol in a mass concentration range of 1.2- 2,5%; and (b) Amino acid derivative in a mass concentration range of 1.0 to 1.25%. 72 32. The synergistic beverage composition for reducing CNS stress and immunology as claimed in claim 1, comprising (a) Saponin Glycoside in a mass concentration range of 0.1%; and (b) Amino acid derivative in a mass concentration range of 1.0 to 1.25%. 33. The synergistic beverage composition for reducing CNS stress and immunology as claimed in claim 1, comprising (a) Saponin Glycoside in a mass concentration range of 0.04%; and (b) sugar alcohol in a mass concentration range of 0.5 to 1.2%. 34. The synergistic beverage composition as claimed in claims 31, 32 or 33, wherein the reduction of CNS stress is evaluated by measuring the levels of one or more parameter selected from acetylcholine esterase (ACHe), interleukin-12 (IL-12), Brain interleukin-12 (IL-12), Monocyte chemoattractant protein -1 (MCP-1), Brain Monocyte chemoattractant protein -1 (Brain MCP-1) and water maze behavioural aspect. 35. The synergistic beverage composition for reducing hangover as claimed in claim 1, comprising (a) Sugar Alcohol in a mass concentration range of 1.2- 2.5%; and (b) Amino Acid Derivative in a mass concentration range of 1.0 - 1.25%. 36. The synergistic beverage composition for reducing hangover as claimed in claim 1, comprising (a) saponin glycoside in a mass concentration range of 0.1%; and (b) Amino Acid Derivative in a mass concentration range of 1.0 - 1.25%. 37. The synergistic beverage composition for reducing hangover as claimed in claim 1, comprising (a) Sugar Alcohol in a mass concentration range of 0.5-1.2%; and (b) saponin glycoside in a mass concentration range of 0.04%. 38. The synergistic beverage composition as claimed in claims 35, 36 or 37, wherein the reduction of hangover is evaluated by measuring the levels of one or more parameter selected from acetylcholine esterase (ACHe), C-reactive protein (CRP), interleukin-12 (IL-12), brain interleukin-12 (Brain IL-12), Monocyte chemoattractant protein -1 (MCP-1), brain Monocyte chemoattractant protein -1 (Brain MCP-1) and interferon gamma (IFN-Gamma). 39. A process for the preparation of synergistic beverage composition as claimed in claim 1, comprising the steps of: (a) obtaining water or alcohol or alcohol-water mixture; (b) mixing two or three ingredients selected from saponin glycoside, sugar or sugar alcohol and Amino Acid derivative, with the water or alcohol or alcohol-water mixture of step (a); (c) adjusting the pH of the resulting solution of step (b) between 4.0 - 9.0; and (d) obtaining the required beverage composition. |