Title:
SYNERGISTIC FORMULATION OF ANTIOXIDANTS AND ANTIMYCOBACTERIAL AGENTS: A METHOD OF MAKING THE SAME
Document Type and Number:
WIPO Patent Application WO2005046567
Kind Code:
B1
Abstract:
The present invention pertains to a six compound pharmaceutical formulation and its process of making comprising of antituberculosis agents like Rifampicin, Isoniazid, Pyrazinamide, and Ethambutal with addition of antioxidants such as d-alpha tocopherol or tocopheryl acetate and pharmaceutically accepted salts thereof and ascorbic acid in required therapeutic quantities for use in treatment of tuberculosis in mammals. This six drug formulation shows synergistic mycobactericidal activity coming along with reduction in oxidative stress, leading to reduction in lung cell damages. The present invention further demonstrates mycobactericidal activity of antioxidants such as d-alpha tocopherol and tocopheryl acetate.
Inventors:
SHELGAONKAR MEENA (IN)
SHELGAONKAR SHRINIWAS (IN)
SHELGAONKAR SHRINIWAS (IN)
Application Number:
PCT/IN2004/000278
Publication Date:
October 27, 2005
Filing Date:
September 08, 2004
Export Citation:
Assignee:
SHELGAONKAR MEENA (IN)
SHELGAONKAR SHRINIWAS (IN)
SHELGAONKAR SHRINIWAS (IN)
International Classes:
A61K9/14; A61K31/355; A61K31/375; A61K45/06; A61P31/06; A61P39/06; A61K; (IPC1-7): A61K9/14; A61P31/06; A61P39/06
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