Title:
SYNOVIOLIN EXPRESSION INHIBITOR CONTAINING MESENCHYMAL STEM CELL OR CULTURE SUPERNATANT THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/079753
Kind Code:
A1
Abstract:
[Problem] To provide a synoviolin expression inhibitor that inhibits expression of a synoviolin gene or a synoviolin protein. [Solution] Provided is a synoviolin expression inhibitor that contains, as an active ingredient, mesenchymal stem cells or a culture supernatant of mesenchymal stem cells and that inhibits synoviolin-gene expression or synoviolin-protein expression. Provided is a synoviolin-expression-inhibitor manufacturing method that includes a step for obtaining the mesenchymal stem cells or the culture supernatant of mesenchymal stem cells by culturing the mesenchymal stem cells by using a serum-free medium and a step for preparing the synoviolin expression inhibitor, which inhibits synoviolin-gene expression or synoviolin-protein expression, by using the mesenchymal stem cells or the culture supernatant of mesenchymal stem cells obtained in the aforementioned step.
Inventors:
URUSHIHATA NAOKI (JP)
TANEMURA HIDEKI (JP)
TAKAGAKI KENTARO (JP)
OKI KATSUYUKI (JP)
NAKAJIMA TOSHIHIRO (JP)
ARATANI SATOKO (JP)
TANEMURA HIDEKI (JP)
TAKAGAKI KENTARO (JP)
OKI KATSUYUKI (JP)
NAKAJIMA TOSHIHIRO (JP)
ARATANI SATOKO (JP)
Application Number:
PCT/JP2017/039013
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
BIOMIMETICS SYMPATHIES INC (JP)
International Classes:
C07G99/00; C12N5/0775; A61K35/28; A61P29/00
Domestic Patent References:
| WO2006137514A1 | 2006-12-28 | |||
| WO2005089800A1 | 2005-09-29 | |||
| WO2015137419A1 | 2015-09-17 | |||
| WO2006137514A1 | 2006-12-28 | |||
| WO2005089800A1 | 2005-09-29 | |||
| WO2015137419A1 | 2015-09-17 | |||
| WO2002052007A1 | 2002-07-04 | |||
| WO2006137514A1 | 2006-12-28 |
Foreign References:
| JP2012157263A | 2012-08-23 | |||
| JP2009155204A | 2009-07-16 | |||
| JP4385076B2 | 2009-12-16 | |||
| JPS5139294B2 | 1976-10-27 | |||
| JPS5526320B2 | 1980-07-12 |
Other References:
AMANO, T. ET AL., GENES & DEVELOPMENT, vol. 17, no. 19, 2003, pages 2436 - 49
YAGISHITA, N. ET AL., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 30, no. 6, 2012, pages 1281 - 6
NAKAJIMA, F. ET AL., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 35, no. 1, 2015, pages 110 - 6
HASEGAWA, D. ET AL., PLOS ONE, vol. 5, no. 10, 2010, pages e13590
YAMASAKI, S. ET AL., THE EMBO JOURNAL, vol. 26, no. 1, 2007, pages 113 - 22
TOH, M.-L. ET AL., ARTHRITIS AND RHEUMATISM, vol. 54, no. 7, 2006, pages 2109 - 18
LE BLANC, K.MOUGIAKAKOS, D., NATURE REVIEWS IMMUNOLOGY, vol. 12, no. 5, 2012, pages 383 - 396
See also references of EP 3533801A4
YAGISHITA, N. ET AL., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 30, no. 6, 2012, pages 1281 - 6
NAKAJIMA, F. ET AL., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 35, no. 1, 2015, pages 110 - 6
HASEGAWA, D. ET AL., PLOS ONE, vol. 5, no. 10, 2010, pages e13590
YAMASAKI, S. ET AL., THE EMBO JOURNAL, vol. 26, no. 1, 2007, pages 113 - 22
TOH, M.-L. ET AL., ARTHRITIS AND RHEUMATISM, vol. 54, no. 7, 2006, pages 2109 - 18
LE BLANC, K.MOUGIAKAKOS, D., NATURE REVIEWS IMMUNOLOGY, vol. 12, no. 5, 2012, pages 383 - 396
See also references of EP 3533801A4
Attorney, Agent or Firm:
HIROSE Takayuki (JP)
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