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Title:
SYNTHESIS OF 2-HYDROXYMETHYLGLUTAMIC ACID AND CONGENERS THEREOF
Document Type and Number:
WIPO Patent Application WO2002022622
Kind Code:
A3
Abstract:
One aspect of the present invention relates to 2-hydroxymethylglutamic acid and congeners thereof. A second aspect of the invention relates to a method of synthesizing 2-hydroxymethylglutamic acid and congeners thereof.

Inventors:
KOZIKOWSKI ALAN P
Application Number:
US0142181W
Publication Date:
April 17, 2003
Filing Date:
September 13, 2001
Export Citation:
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Assignee:
GEORGETOWN UNIVERSITY
International Classes:
C07C229/24; C07D263/06; C07D498/04; (IPC1-7): C07D498/04; C07D263/06; A61K31/195; C07C229/24
Other References:
BR[UNER-OSBORNE H. ET AL.: "Ligands for glutamate receptors: design and therapeutic prospects" JOURNAL OF MEDICINAL CHEMISTRY., vol. 43, no. 14, - 13 July 2000 (2000-07-13) pages 2609-2645, XP002213546 AMERICAN CHEMICAL SOCIETY. WASHINGTON., US ISSN: 0022-2623
ESCRIBANO A ET AL: "(2S,4S)-2-amino-4- (2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 7, 7 April 1998 (1998-04-07), pages 765-770, XP004136962 ISSN: 0960-894X cited in the application
SEEBACH D. ET AL.: "Stereoselektive Alkylierung an C(alpha) von Serin, Glycerins{ure, Threonin und Weins{ure }ber heterocyclische Enolate mit exocyclischer Doppelbindung." HELVETICA CHIMICA ACTA., vol. 70, no. 4, 1987, pages 1194-1216, XP002213547 VERLAG HELVETICA CHIMICA ACTA. BASEL., CH ISSN: 0018-019X cited in the application
CAGNON J R ET AL: "Unusual Regiochemistry of Cycloaddition of Ketenes to (R)-2-tert-Butyldihydrooxazole Derivatives. A Simple Route towards Enantiomerically Pure Functionalised alpha-Aminocyclobutanones" TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 38, no. 13, 31 March 1997 (1997-03-31), pages 2291-2294, XP004056653 ISSN: 0040-4039 cited in the application
W]NSCH B. ET AL.: "Stereoselektive Synthese neuer zentral wirksamer Tricyclen vom Benzomorphan-Typ mit 2-Phenylethylamin Partialstruktur." ARCHIV DER PHARMAZIE., vol. 326, no. 2, 1993, pages 101-113, XP008008011 VERLAG CHEMIE. WEINHEIM., DE cited in the application
ZHANG J. ET AL.: "A tandem Michael addition ring-closure route to the metabotropic receptor ligand alpha-(hydroxymethyl)glutamic acid and its gamma-alkylated derivatives." JOURNAL OF ORGANIC CHEMISTRY., vol. 66, no. 22, - 2 November 2001 (2001-11-02) pages 7555-7559, XP002213548 AMERICAN CHEMICAL SOCIETY. EASTON., US ISSN: 0022-3263
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