Title:
SYNTHESIS OF (R)-3-(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-a]IMIDAZOL-2-ONE
Document Type and Number:
WIPO Patent Application WO2002012243
Kind Code:
A3
Abstract:
A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-a]imidazol-2-one (1). This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
Inventors:
FRUTOS ROGELIO P
JOHNSON MICHAEL DALE
JOHNSON MICHAEL DALE
Application Number:
PCT/US2001/023996
Publication Date:
June 20, 2002
Filing Date:
July 31, 2001
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (US)
International Classes:
A61K31/4188; A61P29/00; A61P43/00; C07C275/24; C07D233/88; C07D487/04; C07F9/6561; (IPC1-7): C07D487/04; C07D233/88; C07F9/6596; C07C275/24; C07C273/18
Domestic Patent References:
WO2001007440A1 | 2001-02-01 |
Foreign References:
US5484802A | 1996-01-16 |
Other References:
KOO LEE ET AL: "The Reaction of Vinyl Phosphates with Iodotrimethylsilane: Synthesis of Vinyl Iodides from Ketones", TETRAHEDRON LETTERS, vol. 34, no. 15, 1993, pages 2433 - 6, XP002194538
H. TAKAHATA ET AL: "An Asymmetric Total Synthesis of (-)-Supinidine", TETRAHEDRON, vol. 47, no. 36, 1991, pages 7635 - 44, XP002194539
K. C. NICOLAOU ET AL: "Synthesis of N-heterocycles via lactam-derived ketene aminal phosphates. Asymmetric synthesis of cyclic amino acids", CHEMICAL COMMUNICATIONS, 1998, pages 1757 - 8, XP002194540
H. TAKAHATA ET AL: "An Asymmetric Total Synthesis of (-)-Supinidine", TETRAHEDRON, vol. 47, no. 36, 1991, pages 7635 - 44, XP002194539
K. C. NICOLAOU ET AL: "Synthesis of N-heterocycles via lactam-derived ketene aminal phosphates. Asymmetric synthesis of cyclic amino acids", CHEMICAL COMMUNICATIONS, 1998, pages 1757 - 8, XP002194540
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