SYNTHESIS OF ABIRATERONE AND RELATED COMPOUNDS

WIPO Patent Application WO/2013/030410

A3

The present invention relates to processesfor obtaining abirateroneand derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C-C coupling through a steroid hydrazone of general formula (II), as well as to intermediates useful in said processes.

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PEREZ ENCABO ALFONSO (ES)
TURIEL HERNANDEZ JOSE ANGEL (ES)
GALLO NIETO FRANCISCO JAVIER (ES)
LORENTE BONDE-LARSEN ANTONIO (ES)
SANDOVAL RODRIGUEZ CELSO MIGUEL (ES)

PCT/EP2012/076380

June 20, 2013

December 20, 2012

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CRYSTAL PHARMA SAU (ES)

C07J41/00; C07J43/00; C07J75/00

WO2012083112A2

2012-06-21

EP0721461A1

1996-07-17

ATTANASI ORAZIO ET AL: "Effect of metals ions in organic synthesis. Part 19. Selective regeneration of carbonyl and hydroxy groups by copper(II) chloride-promoted hydrolysis of tosylhydrazones and acetates", JOURNAL OF CHEMICAL RESEARCH, SCIENCE REVIEWS LTD, GB, vol. Synopses, 1 January 1983 (1983-01-01), pages 322 - 323, XP008152605, ISSN: 0308-2342
ORTAR G: "Palladium-catalyzed cross-coupling reaction of allyl acetates with pinacol aryl- and vinylboronates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 44, no. 23, 2 June 2003 (2003-06-02), pages 4311 - 4314, XP004423968, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(03)00980-8

ARIAS SANZ, Juan (S.L.Avenida de Burgo, 16D Madrid, ES)

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