Title:
SYNTHESIS OF (DIBROMOCYCLOBUTA) AROMATIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2002102810
Kind Code:
A3
Abstract:
A method for the synthesis of cyclobuta aromatic compounds by cyclizing two ortho dibromoalkyl substituents is described. Using a mediator, such as nickel metal, and continuous removal of product from contact with the mediator, high product yields are achieved. A method for bromination of ortho alkyl substituents of aromatic compounds is also described.
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Inventors:
STANGER AMNON (IL)
Application Number:
PCT/US2002/018251
Publication Date:
December 24, 2003
Filing Date:
June 12, 2002
Export Citation:
Assignee:
TECHNION RES & DEV FOUNDATION (IL)
STANGER AMNON (IL)
FRIEDMAN MARK M (IL)
STANGER AMNON (IL)
FRIEDMAN MARK M (IL)
International Classes:
C07B39/00; C07C17/14; C07C17/23; C07C22/04; C07C23/18; B01J23/755; (IPC1-7): C07C17/00; C07C19/00; C07C19/08; C07C21/00; C07C21/18; C07C22/00; C07C23/00; C07C23/18; C07C25/00
Foreign References:
| US5552508A | 1996-09-03 |
Other References:
AMNON STANGER ET AL.: "Nickel mediated cyclobutabenzenes synthesis", J. ORG. CHEM., vol. 61, no. 7, 1996, pages 2549 - 2552, XP002961649
AMNON STANGER ET AL: "Stereocontrol in nickel mediated synthesis of cyclobutabenzenes", TETRAHEDRON, vol. 54, no. 7, 1998, pages 1207 - 1220, XP004106698
AMNON STANGER ET AL: "Stereocontrol in nickel mediated synthesis of cyclobutabenzenes", TETRAHEDRON, vol. 54, no. 7, 1998, pages 1207 - 1220, XP004106698
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