SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF

WIPO Patent Application WO1999001124

A9

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

WO/1998/032444	USE OF FXR, PPAR$g(a) AND LXR$g(a) ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION
WO/2012/083493	MEDICINAL COMPOSITION
WO/2010/042841	COMBINATION THERAPIES FOR THE TREATMENT OF DEGENERATIVE INFLAMMATORY CONDITIONS OF THE NERVOUS SYSTEM

DANISHEFSKY SAMUEL J
BALOG AARON
BERTINATO PETER
SU DAI-SHI
CHOU TING-CHAU
MENG DONG FANG
KAMENECKA TED
SORENSEN ERIK J

PCT/US1997/022381

May 14, 1999

December 03, 1997

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SLOAN KETTERING INST CANCER (US)

A61K31/335; A61K31/337; A61K31/422; A61K31/425; A61K31/426; A61K31/429; A61K31/475; A61K31/70; A61K35/00; A61K45/06; C07C33/02; C07C43/12; C07C47/277; C07C69/007; C07C69/716; C07C69/738; C07C323/14; C07D263/32; C07D277/22; C07D277/24; C07D277/30; C07D313/00; C07D413/06; C07D417/06; C07D417/14; C07D493/04; C07F5/02; C07F7/18; C07D277/06; (IPC1-7): A61K31/34; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/585; A61K31/70; C07H17/02; C07H17/04; C07D209/08; C07D211/82; C07D213/28; C07D233/54; C07D233/56; C07D233/64; C07D263/32; C07D277/24; C07D303/14; C07D307/36; C07D317/18; C07D317/26; C07D405/06; C07D405/14; C07D409/06; C07D409/14; C07D413/06; C07D413/14; C07D417/06; C07D417/14

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