SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF

WIPO Patent Application WO2001064650

A3

The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.

WO/1999/043653	SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF
JP2004529911	3,4-Disubstituted cyclobutene-1,2-dione as a CXC chemokine receptor antagonist

DANISHEFSKY SAMUEL J (US)
LEE CHUL BOM (US)
CHAPPELL MARK (US)
STACHEL SHAWN (US)
CHOU TING-CHAO (US)

PCT/US2001/006643

May 10, 2002

March 01, 2001

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SLOAN KETTERING INST CANCER (US)
DANISHEFSKY SAMUEL J (US)
LEE CHUL BOM (US)
CHAPPELL MARK (US)
STACHEL SHAWN (US)
CHOU TING CHAO (US)

C07D277/24; A61K31/337; A61K31/427; A61K31/475; A61K31/704; A61K47/48; A61P35/00; A61P35/02; A61P41/00; A61P43/00; C07B61/00; C07C45/64; C07C49/24; C07C68/00; C07C69/96; C07C327/28; C07D417/06; C07D417/14; C07D491/044; C07D493/04; C07F7/18; (IPC1-7): C07D225/02; A61K31/427; A61P35/00; C07D315/00; C07D417/06

HARRIS C R ET AL: "COMPLEX TARGET-ORIENTED SYNTHESIS IN THE DRUG DISCOVERY PROCESS: A CASE HISTORY IN THE DEPOB SERIES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 64, 1999, pages 8434 - 8456, XP000984318, ISSN: 0022-3263
NICOLAOU K C ET AL: "Chemical Biology of Epothilones", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 37, no. 15, August 1998 (1998-08-01), pages 2014 - 2045, XP002131418, ISSN: 0570-0833

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