Title:
SYNTHESIS OF ERIBULIN MESYLATE
Document Type and Number:
WIPO Patent Application WO/2022/257271
Kind Code:
A1
Abstract:
The present invention relates to the synthesis of eribulin mesylate, and specifically provides a method for preparing an intermediate compound of eribulin mesylate represented by formula II ((1R,2S,3S,4S,5S,6R,11S,14S,17S,19R,21R,23S,25R,26R,27S,31R,34S)-25-[(2S)-2,3-bishydroxyl ]-2,5-Dihydroxy-26-methoxy-19-methyl-13,20-bismethylene-24,35,36,37,38,39-hexaoxacyclo[29.3.1.13,6.14,34.111,14.117,21.023,27 ]nonacosane-8,29-dione). The present invention aims to avoid the problem of low reaction yield of conventional synthetic routes.
Inventors:
QIU XIAOLONG (CN)
XU TAO (CN)
ZUO ZHIWEI (CN)
GE JIE (CN)
LU XINWEI (CN)
CHU LINGLING (CN)
LIU WENBO (CN)
WANG BIAO (CN)
GU TINGWEI (CN)
WANG WEIWEI (CN)
HU LIN (CN)
ZOU PING (CN)
CHEN JUN (CN)
CAO LEI (CN)
XU TAO (CN)
ZUO ZHIWEI (CN)
GE JIE (CN)
LU XINWEI (CN)
CHU LINGLING (CN)
LIU WENBO (CN)
WANG BIAO (CN)
GU TINGWEI (CN)
WANG WEIWEI (CN)
HU LIN (CN)
ZOU PING (CN)
CHEN JUN (CN)
CAO LEI (CN)
Application Number:
PCT/CN2021/113477
Publication Date:
December 15, 2022
Filing Date:
August 19, 2021
Export Citation:
Assignee:
WISDOM PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D493/22; C07D307/28; C07D493/04
Domestic Patent References:
| WO2016031796A1 | 2016-03-03 |
Foreign References:
| CN105916861A | 2016-08-31 | |||
| CN109694379A | 2019-04-30 | |||
| CN110922423A | 2020-03-27 |
Attorney, Agent or Firm:
CHANGZHOU BAIYETENGFEI PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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