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Patent Searching and Data


Title:
SYNTHESIS METHOD FOR CARIPRAZINE
Document Type and Number:
WIPO Patent Application WO/2020/042876
Kind Code:
A1
Abstract:
The present application relates to a synthesis method for cariprazine, comprising performing an acylation reaction between a compound represented by formula (I) and dimethylcarbamoyl chloride in a reaction solvent in the presence of an aqueous solution of an inorganic base, so as to obtain the cariprazine compound represented by formula (II). The synthesis method overcomes defects in the prior art such as a long reaction time, large size impurities and the difficulty of purification, and provides a new method suitable for commercial production wherein the reaction is fast, impurity sizes are small, the product is easily purified, the purity of the product can reach 99.0% or more, and the yield is high.

Inventors:
LIAO WENJING (CN)
GE JIANFENG (CN)
ZHANG JICHENG (CN)
HUANG LUNING (CN)
TAO ANPING (CN)
GU ERIC (CN)
Application Number:
PCT/CN2019/099374
Publication Date:
March 05, 2020
Filing Date:
August 06, 2019
Export Citation:
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Assignee:
ZHEJIANG HUAHAI PHARM CO LTD (CN)
SHANGHAI SYNCORES TECH INC LTD (CN)
International Classes:
C07D295/135
Domestic Patent References:
WO2005012266A12005-02-10
Foreign References:
CN106543039A2017-03-29
CN105330616A2016-02-17
CN102256955A2011-11-23
CN106518841A2017-03-22
CN201810993813A2018-08-29
CN105330616A2016-02-17
Other References:
See also references of EP 3845523A4
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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