Title:
SYNTHESIS METHOD FOR CYCLOPROPYL-CONTAINING CHIRAL AMINE HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2022/126942
Kind Code:
A1
Abstract:
The present invention relates to the field of synthesis and preparation of medical intermediates. Disclosed is a synthesis method for a medical intermediate cyclopropyl-containing chiral amine hydrochloride. According to the present invention, a compound (I) cycloprogyl dehyde is used as an initial raw material, and a target product chiral amine hydrochloride is obtained by means of condensation, alkylation, debenzylation, chiral resolution and salification reactions. The synthesis method for the medical intermediate cyclopropyl-containing chiral amine hydrochloride in the present invention has the characteristics of low cost and simple operation.
Inventors:
FENG YU (CN)
QIAN WEI (CN)
DANG JUNKUI (CN)
HUANG XING (CN)
ZHONG CHENHAO (CN)
WANG ZHIPENG (CN)
LI MIAOBIN (CN)
GAO LIYAN (CN)
XU YANPING (CN)
BIAN JISHUN (CN)
QIAN WEI (CN)
DANG JUNKUI (CN)
HUANG XING (CN)
ZHONG CHENHAO (CN)
WANG ZHIPENG (CN)
LI MIAOBIN (CN)
GAO LIYAN (CN)
XU YANPING (CN)
BIAN JISHUN (CN)
Application Number:
PCT/CN2021/086610
Publication Date:
June 23, 2022
Filing Date:
April 12, 2021
Export Citation:
Assignee:
CHENGDA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07C209/62; C07C209/68; C07C209/74; C07C211/17; C07C211/25; C07C211/27; C07C249/02; C07C251/18
Domestic Patent References:
| WO2020079145A1 | 2020-04-23 |
Foreign References:
| CN112552184A | 2021-03-26 | |||
| CN110520406A | 2019-11-29 | |||
| CN1989097A | 2007-06-27 |
Attorney, Agent or Firm:
BEIJING KEYI INTELLECTUAL PROPERTY FIRM (CN)
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