Title:
SYNTHESIS METHOD FOR HIGH-PURITY CHOLESTEROL
Document Type and Number:
WIPO Patent Application WO/2023/142890
Kind Code:
A1
Abstract:
Disclosed in the present invention is a synthesis method for high-purity cholesterol. The cholesterol is synthesized by using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, which is also referred to as bisnoralcohol or BA, as a raw material, and by means of steps of oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, and deprotection or hydrolysis reaction, and the purity can reach 99% or above. Aiming at defects of conventional animal-derived cholesterol, in the present invention, the cholesterol is synthesized from plant-derived raw material BA; thus, high safety is achieved, the risk of pathogenic bacteria and virus infection is avoided, high synthesis yield, high product purity, and environmental friendliness are achieved, and industrial production is facilitated. Moreover, the impurity level in the product is greatly reduced by the route in the present invention, high-purity cholesterol can be obtained conveniently, and the safety of clinical use is improved.
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Inventors:
QIU WENWEI (CN)
GU XIANGZHONG (CN)
LI CHENCHEN (CN)
JIANG CHENGYU (CN)
YE RUFEI (CN)
GU XIANGZHONG (CN)
LI CHENCHEN (CN)
JIANG CHENGYU (CN)
YE RUFEI (CN)
Application Number:
PCT/CN2022/144100
Publication Date:
August 03, 2023
Filing Date:
December 30, 2022
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
JIANGSU JIAERKE PHARMACEUTICALS GROUP CORP LTD (CN)
JIANGSU JIAERKE PHARMACEUTICALS GROUP CORP LTD (CN)
International Classes:
C07J9/00
Foreign References:
| CN113248557A | 2021-08-13 | |||
| CN113943336A | 2022-01-18 | |||
| CN114395009A | 2022-04-26 | |||
| CN114524856A | 2022-05-24 | |||
| CN114874277A | 2022-08-09 | |||
| CN112608361A | 2021-04-06 |
Other References:
JIANG JING-SONG; ZHAO HOU-FA; ZHANG WEI-XIU; ANHUI KEBAO: "Refinement of cholesterol with isopropyl alcohol", MODERN CHEMICAL INDUSTRY, HUAXUE GONGYE BU KEXUE JISHU QINGBAO YANJIUSUO, BEIJING, CN, vol. 34, no. 9, 30 September 2014 (2014-09-30), CN , pages 80 - 81, 83, XP009547817, ISSN: 0253-4320
XINYU MA, LIU XIAOFANG, ZHOU GANG: "New Process for Cholesterol Separation and Purification", XINJIANG JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 20, no. 4, 25 August 2002 (2002-08-25), pages 9 - 10, XP093082100
XINYU MA, LIU XIAOFANG, ZHOU GANG: "New Process for Cholesterol Separation and Purification", XINJIANG JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 20, no. 4, 25 August 2002 (2002-08-25), pages 9 - 10, XP093082100
Attorney, Agent or Firm:
MSJLAW OFFICE (CN)
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