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Title:
SYNTHESIS METHOD OF PROLINE-HISTIDINE CYCLODIPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2018/126523
Kind Code:
A1
Abstract:
The invention provides a synthesis method of a proline-histidine cyclodipeptide, comprising: preparing an amino-protected proline-histidine dipeptide methyl ester from histidine and proline, wherein one of histidine and valine is a methyl ester hydrochloride form, the other is an amino protected form; deprotecting the amino-protected proline-histidine dipeptide methyl ester and ring synthesizing the proline-histidine cyclodipeptide.

Inventors:
WANG, Huijia (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
WANG, Hui (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
SU, Chencan (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
ZHANG, Zhongqi (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
LI, Qian (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
WANG, Wanke (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
GAO, Changbo (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
GUO, Tian (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
HAN, Guang (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
ZHAO, Jinli (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
YANG, Xiaolin (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
Application Number:
CN2017/075123
Publication Date:
July 12, 2018
Filing Date:
February 28, 2017
Export Citation:
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Assignee:
SHAANXI HUIKANG BIO-TECH CO., LTD (4F Bao Sai Building, Technology Park of Xi'an Jiaotong UniversityYan Xiang Road, Yanta Distric, Xi'an Shaanxi 4, 710054, CN)
International Classes:
C07K5/12; C07D487/04
Foreign References:
CN102093470A2011-06-15
CN104447759A2015-03-25
CN1951954A2007-04-25
Other References:
ZHANG, YANRONG ET AL.: "Opltimization of High Pressure/Temperature Assisted Synthesis of Cyclo(His-Pro", FOOD SCIENCE, vol. 37, no. 8, 18 February 2016 (2016-02-18), XP055513319, ISSN: 1002-6630
QIN, XIANCAN ET AL.: "Synthesis of Cyclodipeptide Cyclo(L-His-L-Pro", JOURNAL OF HAINAN NORMAL UNIVERSITY, vol. 21, no. 2, 30 June 2008 (2008-06-30), pages 173 - 175, ISSN: 1674-4942
Attorney, Agent or Firm:
HYLANDS LAW FIRM (Unit 1511, 15/F Tower A, Full Link Plaza,No. 18 Chaoyangmenwai Ave.,Chaoyang District, Beijing 0, 100020, CN)
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