Title:
SYNTHESIS OF OLIGOKETIDES
Document Type and Number:
WIPO Patent Application WO2000044717
Kind Code:
A3
Abstract:
Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as to form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.
Inventors:
ASHLEY GARY (US)
CHAN-KAI ISAAC CHU-WAH (US)
BURLINGAME MARK ALMA (US)
CHAN-KAI ISAAC CHU-WAH (US)
BURLINGAME MARK ALMA (US)
Application Number:
PCT/US2000/002397
Publication Date:
February 08, 2001
Filing Date:
January 27, 2000
Export Citation:
Assignee:
KOSAN BIOSCIENCES INC (US)
ASHLEY GARY (US)
CHAN KAI ISAAC CHU WAH (US)
BURLINGAME MARK ALMA (US)
ASHLEY GARY (US)
CHAN KAI ISAAC CHU WAH (US)
BURLINGAME MARK ALMA (US)
International Classes:
C07B53/00; C07C327/30; C07D209/48; C12P17/08; C07D213/55; C07D239/38; C07D277/20; C07D277/30; C07D307/16; C12N1/20; C40B40/02; C40B40/04; C40B50/00; C40B50/06; (IPC1-7): C07C327/30; C12P17/08; C07D239/38
Domestic Patent References:
| WO1999003986A2 | 1999-01-28 |
Other References:
O. MIYATA, ET AL.: "An efficient method for the removal of chiral auxilliaries, camphorsultam and 4-isopropyl-2-oxazolidinone", SYNLETT, no. 8, August 1994 (1994-08-01), Thieme Verlag, Stuttgart, DE, pages 637 - 638, XP002140427, ISSN: 0936-5214
C.M. KAO, ET AL.: "Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase", BIOCHEMISTRY, vol. 35, no. 38, 1 January 1996 (1996-01-01), American Chemcial Society, Washington, DC, US, pages 12363 - 12368, XP002082318, ISSN: 0006-2960
C. LE SANN, ET AL.: "A general synthesis of homochiral beta-hydroxy N-acetylcysteamine thioesters", TETRAHEDRON LETTERS, vol. 40, no. 21, 21 May 1999 (1999-05-21), Elsevier Science Publishers, Amsterdam, NL, pages 4093 - 4096, XP004164620, ISSN: 0040-4039
C.M. KAO, ET AL.: "Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase", BIOCHEMISTRY, vol. 35, no. 38, 1 January 1996 (1996-01-01), American Chemcial Society, Washington, DC, US, pages 12363 - 12368, XP002082318, ISSN: 0006-2960
C. LE SANN, ET AL.: "A general synthesis of homochiral beta-hydroxy N-acetylcysteamine thioesters", TETRAHEDRON LETTERS, vol. 40, no. 21, 21 May 1999 (1999-05-21), Elsevier Science Publishers, Amsterdam, NL, pages 4093 - 4096, XP004164620, ISSN: 0040-4039
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