Title:
SYNTHESIS AND PHARMACEUTICALS OF NOVEL 9-SUBSTITUTED-1,5-DICHLOROANTHRACENE ANALOGS
Document Type and Number:
WIPO Patent Application WO2000061536
Kind Code:
A3
Abstract:
The invention relates to novel anthracene compounds useful in the treatment of allergic, inflammatory conditions, tumor conditions and therapeutic compositions containing such compounds. The compounds of the present invention are 9-acyloxy-substituted 1,5-dichloro-anthracene, analogs and salts thereof. According to the practice of the invention, there are provided 9-acyloxy substituted 1,5-dichloroanthracene compounds according to the formula RC(O)O-X, where X is the 1,5-dichloroanthracene nucleus, the group RC(O)O- is attached to the 1,5-dichloroanthracene nucleus at the 9-position and wherein R represents a straight or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R1, or R represents phenyl or benzyl which may be substituted with one or two groups of R2; wherein R1 is selected from the group consisting of halogen, -NO2, -OCH3, -OCH2CH3 and -OCH2CH2CH3; and wherein R2 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, -NO2, -OCH3, -OCH2CH3 and -OCH2CH2CH3.
Inventors:
HUANG HSU-SHAN
LEE KUNG-YUANG
SHI CHANG-HSIN
HSU HSIEN-CHIN
LEE KUNG-YUANG
SHI CHANG-HSIN
HSU HSIEN-CHIN
Application Number:
PCT/US2000/009467
Publication Date:
April 26, 2001
Filing Date:
April 10, 2000
Export Citation:
Assignee:
GLOBOASIA L L C (US)
International Classes:
A61K31/216; A61K31/222; C07C67/00; C07C69/00; C07C205/57; (IPC1-7): C07C69/63; A61K31/215; C07C69/017; C07C69/035; C07C69/76
Foreign References:
| EP0731078A1 | 1996-09-11 | |||
| US4755530A | 1988-07-05 |
Other References:
CHEMICAL ABSTRACTS, vol. 88, no. 13, 27 March 1978, Columbus, Ohio, US; abstract no. 83369t, ZEE-CHENG R.: "Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkyl-amino)anthraquinones" XP002901368
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