Title:
SYNTHESIS, PREPARATION METHOD AND USE OF SHP2 AND CDK4/6 DUAL-TARGET INHIBITORY COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/071314
Kind Code:
A1
Abstract:
The present invention belongs to the field of medicinal chemistry, and particularly relates to synthesis, a preparation method and the use of an inhibitor containing dual targets SHP2 and CDK4/6, wherein the inhibitor comprises three compounds of general formulas I-III and pharmaceutically acceptable salts, enantiomers, diastereomers, tautomers, solvates, polymorphs or prodrugs thereof. According to the present invention, a class of brand-new SHP2 and CDK4/6 dual-target inhibitors are prepared by means of a pharmacophore fusion and reasonable drug design method, so that the problems of drug resistance, poor drug effect, etc., of the existing SHP2 inhibitor and CDK4/6 inhibitor are solved; the great significance of the present invention is providing the first SHP2 and CDK4/6 dual-target inhibitor, which provides a basis for solving the problem of drug resistance of kinase and phosphatase in the later period; in addition, the embodiments of the present invention prove that the SHP2 inhibitor and the CDK4/6 inhibitor have a synergistic effect, which provides a theoretical support for the subsequent development of SHP2 dual-target inhibitors.
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Inventors:
WU XIAOXING (CN)
CHEN XIAOYU (CN)
LI WENQIANG (CN)
SHU CHENGXIA (CN)
LUO GUANGMEI (CN)
YANG KEXIN (CN)
CHEN XIAOYU (CN)
LI WENQIANG (CN)
SHU CHENGXIA (CN)
LUO GUANGMEI (CN)
YANG KEXIN (CN)
Application Number:
PCT/CN2022/106982
Publication Date:
May 04, 2023
Filing Date:
July 21, 2022
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D487/04; A61K31/497; A61P35/00; C07D241/02; C07D241/26; C07D401/04; C07D401/14; C07D405/14; C07D491/107
Domestic Patent References:
| WO2020076723A1 | 2020-04-16 | |||
| WO2020216371A1 | 2020-10-29 | |||
| WO2020073949A1 | 2020-04-16 | |||
| WO2021110122A1 | 2021-06-10 | |||
| WO2021142026A1 | 2021-07-15 | |||
| WO2021259077A1 | 2021-12-30 |
Foreign References:
| CN114302878A | 2022-04-08 | |||
| CN110382495A | 2019-10-25 | |||
| CN113968824A | 2022-01-25 | |||
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| CN113461670A | 2021-10-01 | |||
| CN112203653A | 2021-01-08 | |||
| CN112203689A | 2021-01-08 |
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (CN)
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