Title:
SYNTHESIS OF SUBSTANTIALLY DIASTEREOMERICALLY PURE PHOSPHATE PROTIDES
Document Type and Number:
WIPO Patent Application WO/2018/229493
Kind Code:
A3
Abstract:
The present invention generally relates to a process for the preparation of certain anticancer compounds as specific phosphate diastereoisomers.
Inventors:
GRIFFITH HUGH (GB)
KENNOVIN GORDON (GB)
DAMMALAPATI VENKATA LAKSHMI NARASIMHA RAO (IN)
KOTALA MANI BUSHAN (IN)
KENNOVIN GORDON (GB)
DAMMALAPATI VENKATA LAKSHMI NARASIMHA RAO (IN)
KOTALA MANI BUSHAN (IN)
Application Number:
PCT/GB2018/051638
Publication Date:
February 07, 2019
Filing Date:
June 14, 2018
Export Citation:
Assignee:
NUCANA PLC (GB)
International Classes:
C07H1/02; C07F9/24; C07H19/10; C07H19/20
Domestic Patent References:
| WO2016030335A1 | 2016-03-03 | |||
| WO2016083830A1 | 2016-06-02 | |||
| WO2017207989A1 | 2017-12-07 | |||
| WO2016098123A2 | 2016-06-23 | |||
| WO2017087517A1 | 2017-05-26 |
Other References:
BRUCE S. ROSS ET AL: "Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 20, 21 October 2011 (2011-10-21), pages 8311 - 8319, XP055137289, ISSN: 0022-3263, DOI: 10.1021/jo201492m
BRYON SIMMONS ET AL: "Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189", ORGANIC LETTERS, vol. 19, no. 9, 18 April 2017 (2017-04-18), US, pages 2218 - 2221, XP055507907, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00469
CHRISTOPHER MCGUIGAN ET AL: "Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 20, 27 October 2011 (2011-10-27), pages 7247 - 7258, XP055023640, ISSN: 0022-2623, DOI: 10.1021/jm200815w
MICHAELA SERPI ET AL: "Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine", CHEMISTRY OPEN, vol. 6, no. 3, 5 May 2017 (2017-05-05), pages 424 - 436, XP055508703, ISSN: 2191-1363, DOI: 10.1002/open.201700019
BRYON SIMMONS ET AL: "Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189", ORGANIC LETTERS, vol. 19, no. 9, 18 April 2017 (2017-04-18), US, pages 2218 - 2221, XP055507907, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00469
CHRISTOPHER MCGUIGAN ET AL: "Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 20, 27 October 2011 (2011-10-27), pages 7247 - 7258, XP055023640, ISSN: 0022-2623, DOI: 10.1021/jm200815w
MICHAELA SERPI ET AL: "Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine", CHEMISTRY OPEN, vol. 6, no. 3, 5 May 2017 (2017-05-05), pages 424 - 436, XP055508703, ISSN: 2191-1363, DOI: 10.1002/open.201700019
Attorney, Agent or Firm:
HGF LIMITED (GB)
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