Title:
SYNTHESIS OF SULFAMIDATES
Document Type and Number:
WIPO Patent Application WO2003066549
Kind Code:
A3
Abstract:
A regio- and stereoselective two-stage synthesis of beta-aminoalcohols employs a key transformation, viz., the creation of a cyclic sulfamidate from a precursor diol, mediated by Burgess-type reagents. The generality and scope of this approach is underscored by the considerable number and variety of substrates which display high levels of selectivity in the process. As such, this method provides facile access to compounds for use in myriad applications, whether as chiral ligands to perform asymmetric synthesis or as molecular probes to explore problems in chemical biology.
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Inventors:
NICOLAOU KYRIACOS C (US)
SNYDER SCOTT A (US)
HUANG XIANHAI (US)
SNYDER SCOTT A (US)
HUANG XIANHAI (US)
Application Number:
PCT/US2003/003788
Publication Date:
March 25, 2004
Filing Date:
February 07, 2003
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
NICOLAOU KYRIACOS C (US)
SNYDER SCOTT A (US)
HUANG XIANHAI (US)
NICOLAOU KYRIACOS C (US)
SNYDER SCOTT A (US)
HUANG XIANHAI (US)
International Classes:
C07C269/06; C07C307/06; C07D291/04; C07D419/14; C07C271/16; (IPC1-7): C07C331/00; A61K31/55; C07D513/04
Foreign References:
| US5506355A | 1996-04-09 | |||
| US5998412A | 1999-12-07 |
Other References:
DATABASE CAPLUS [online] NICOLAOU ET AL.: "A new method for the synthesis of nonsymmetrical sulfamides using Burgess-type reagents", XP002967233, accession no. STN Database accession no. 2002:859313
DATABASE CAPLUS [online] WOOD ET AL.: "A novel, one-step method for the conversion of primary alcohols into carbamate-protected amines", XP002967234, accession no. STN Database accession no. 2002:338057
DATABASE CAPLUS [online] CRABBE ET AL.: "Novel dehydration reaction of steroidal alcohols", XP002967235, accession no. STN Database accession no. 1970:466808
DATABASE CAPLUS [online] LAMBERT C.: "Burgess reagent", XP002967236, accession no. STN Database accession no. 2000:487725
DATABASE CAPLUS [online] WOOD ET AL.: "A novel, one-step method for the conversion of primary alcohols into carbamate-protected amines", XP002967234, accession no. STN Database accession no. 2002:338057
DATABASE CAPLUS [online] CRABBE ET AL.: "Novel dehydration reaction of steroidal alcohols", XP002967235, accession no. STN Database accession no. 1970:466808
DATABASE CAPLUS [online] LAMBERT C.: "Burgess reagent", XP002967236, accession no. STN Database accession no. 2000:487725
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