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Title:
SYNTHESIZING METAL NANOPARTICLES ON INDIVIDUAL THIOL-RICH TAGS AS SINGLE-MOLECULE PROBES
Document Type and Number:
WIPO Patent Application WO/2019/024707
Kind Code:
A1
Abstract:
Metal nanoparticles are directly synthesized on polymers comprising a plurality of thiol groups to form compositions useful as electron microscopy tags.

Inventors:
HE, Wanzhong (7 Science Park Rd, ZGC Life Science ParkChangping District, Beijing 6, 102206, CN)
JIN, Xiumei (7 Science Park Rd, ZGC Life Science ParkChangping District, Beijing 6, 102206, CN)
Application Number:
CN2018/096753
Publication Date:
February 07, 2019
Filing Date:
July 24, 2018
Export Citation:
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Assignee:
NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (7 Science Park Rd, ZGC Life Science ParkChangping District, Beijing 6, 102206, CN)
International Classes:
C07K19/00; C07F1/12; C12Q1/68; C40B40/10; G01N33/48; G01N33/50
Domestic Patent References:
WO2007122259A12007-11-01
WO2016118084A12016-07-28
Foreign References:
CN105801703A2016-07-27
US20040038264A12004-02-26
Other References:
HE WANZHONG: "Highlighting individual proteins in cellular context by synthesizing gold nanoparticles on clonable EM tags in situ", PROCEEDINGS OF THE FOURTH NATIONAL SYMPOSIUM ON CRYO ELECTRON MICROSCOPY AND STRUCTURAL BIOLOGY, 8 June 2015 (2015-06-08)
LI JIANFANG ET AL.: "Highly selective and sensitive detection of glutathione based on anti- aggregation of gold nanoparticles via pH regulation", SENSORS AND ACTUATORS B: CHEMICAL, vol. 240, 6 September 2016 (2016-09-06), pages 553 - 559, XP029819037
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