Title:
SYNTHETIC ACTIVE PEPTIDE FRAGMENTS
Document Type and Number:
WIPO Patent Application WO2003082897
Kind Code:
A3
Abstract:
The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequence of specific portions of the 14 kDa protein of S.mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.
Inventors:
TENDLER MIRIAM (BR)
GARRAT RICHARD CHARLES (BR)
KATZ NAFTALE (BR)
SIMPSON ANDREW JOHN GEORGE (BR)
DE BARRIENTOS FRANK JEFFERSON
VILAR MONICA MAGNO (BR)
ALMEIDA MARILIA SIRIANNI DOS S (BR)
GARRAT RICHARD CHARLES (BR)
KATZ NAFTALE (BR)
SIMPSON ANDREW JOHN GEORGE (BR)
DE BARRIENTOS FRANK JEFFERSON
VILAR MONICA MAGNO (BR)
ALMEIDA MARILIA SIRIANNI DOS S (BR)
Application Number:
PCT/BR2003/000051
Publication Date:
December 18, 2003
Filing Date:
April 01, 2003
Export Citation:
Assignee:
FUNDACAO OSWALDO CRUZ (BR)
TENDLER MIRIAM (BR)
GARRAT RICHARD CHARLES (BR)
KATZ NAFTALE (BR)
SIMPSON ANDREW JOHN GEORGE (BR)
DE BARRIENTOS FRANK JEFFERSON
VILAR MONICA MAGNO (BR)
ALMEIDA MARILIA SIRIANNI DOS S (BR)
TENDLER MIRIAM (BR)
GARRAT RICHARD CHARLES (BR)
KATZ NAFTALE (BR)
SIMPSON ANDREW JOHN GEORGE (BR)
DE BARRIENTOS FRANK JEFFERSON
VILAR MONICA MAGNO (BR)
ALMEIDA MARILIA SIRIANNI DOS S (BR)
International Classes:
C07K14/435; A61K39/00; (IPC1-7): C07K14/435; A61K38/17; G01N33/53
Other References:
DATABASE MEDLINE [online] BRITO C.F. ET AL.: "Human IgG1 and IgG3 recognition of schistosoma mansoni 14 kDa fatty acid-binding recombinant protein'", XP002903084, accession no. NCBI Database accession no. 10744504
TENDLER M. ET AL.: "A schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine", PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 269 - 273, XP002903072
THAUMATURGO N. ET AL.: "Preliminary analysis of Sm14 in distinct fractions of schistosoma mansoni adult worm extract", MEM. INST. OSWALDO CRUZ, vol. 96, no. SUPPL., 2001, pages 79 - 83, XP008039743
TENDLER M. ET AL.: "A schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine", PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 269 - 273, XP002903072
THAUMATURGO N. ET AL.: "Preliminary analysis of Sm14 in distinct fractions of schistosoma mansoni adult worm extract", MEM. INST. OSWALDO CRUZ, vol. 96, no. SUPPL., 2001, pages 79 - 83, XP008039743
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