Title:
SYNTHETIC ANALOGUES OF PHOSPHATIDYL-MYO-INOSITOL MANNOSIDES WITH AN INHIBITORY ACTIVITY ON THE INFLAMMATORY RESPONSE
Document Type and Number:
WIPO Patent Application WO/2009/153434
Kind Code:
A8
Abstract:
The present invention relates to novel synthetic analogues of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL‑12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.
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Inventors:
QUESNIAUX RYFFEL VALERIE (FR)
MARTIN OLIVIER (FR)
FRONT SOPHIE (FR)
MARTIN OLIVIER (FR)
FRONT SOPHIE (FR)
Application Number:
PCT/FR2009/000595
Publication Date:
February 24, 2011
Filing Date:
May 20, 2009
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
UNIV ORLEANS (FR)
QUESNIAUX RYFFEL VALERIE (FR)
MARTIN OLIVIER (FR)
FRONT SOPHIE (FR)
UNIV ORLEANS (FR)
QUESNIAUX RYFFEL VALERIE (FR)
MARTIN OLIVIER (FR)
FRONT SOPHIE (FR)
International Classes:
C07H15/207; A61K31/7034; A61P29/00; A61P31/00; A61P37/00
Attorney, Agent or Firm:
NOVAGRAAF TECHNOLOGIES (Levallois-Perret Cedex, FR)
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