Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
A SYNTHETIC METHOD OF 20 (S)-GINSENOSIDE RH2
Document Type and Number:
WIPO Patent Application WO/2006/010307
Kind Code:
A1
Abstract:
A synthetic method of 20 (s)-ginsenoside Rh2, i. e. 20(S)-protopanaxdiol - 3 - 0 - β - D - glucopyranoside, comprising: selectively protecting protopanaxadiol first to afford monosubstituted protopanaxadiol, and Glycosidating the monosubstituted protopanaxadiol with glucopyranosyl donor in the presence of Lewis acid catalyst, deprotecting the product, then separating and purifying to obtain 20 (s)-ginsenoside Rh2. This method is conducted under mild condition at low cost, and affords product with high stereoselectivity in high yield and purity. Therefore, the synthetic method according to the present invention is suitable for production on industrial scale.

Inventors:
HUI YONGZHENG (CN)
YANG ZHIQI (CN)
LIU JUNYAO (CN)
TENG JIJUN (CN)
XIE HUIQIN (CN)
ZHANG JIE (CN)
Application Number:
PCT/CN2005/000675
Publication Date:
February 02, 2006
Filing Date:
May 16, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SHANGHAI INNOVATIVE RES CT OF (CN)
HUI YONGZHENG (CN)
YANG ZHIQI (CN)
LIU JUNYAO (CN)
TENG JIJUN (CN)
XIE HUIQIN (CN)
ZHANG JIE (CN)
International Classes:
C07J9/00; (IPC1-7): C07J17/00; C07J75/00
Foreign References:
JPH08208688A1996-08-13
KR950007250B11995-07-07
KR100293968B12001-09-17
KR940004066B11994-05-11
CN1225366A1999-08-11
Other References:
KIM D-S ET AL: "Ginsenoside Rh2 prepared from enzyme reation", DALIAN QINGGONGYE XUEYUAN YUEBAO, vol. 20, no. 2, June 2001 (2001-06-01), pages 99 - 115
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (Building 3 Jinqiuzhichun Garden, No. 6, Zhichun Roa, Haidian District Beijing 8, CN)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: A METHOD FOR PRODUCING HIGH-PURITY NICKEL

Next Patent: PREPARATION AND APPLICATION OF THERAPEUTIC VACCINES OF TUMOUR