Title:
SYNTHETIC METHOD OF BIVALIRUNDIN
Document Type and Number:
WIPO Patent Application WO/2019/241903
Kind Code:
A1
Abstract:
The Active Pharmaceutical Ingredient (API), Bivalirudin, is a 20 amino acid peptide containing one basic and 5 amino acid residues. With a chemical formula of C98H138N24O33 and a molecular weight of 2180.3 g/mol. Bivalirudin is also known as Angiomax. It is a direct thrombin inhibitor indicated for use as an anticoagulant. It provides a method for synthesizing bivalirudin and in particular to the synthetic method of bivalirudin by solid phase peptide synthesis using Fmoc-Leu-Wang resin as a carrier. The method has the advantages of high yield, less by-product and simple separation and purification, and it's time gaining than the prior art, and is suitable for pilot and industrial production.
Inventors:
BONAVENTURA IVAN DI (CN)
HE RUNZE (CN)
HE RUNZE (CN)
Application Number:
PCT/CN2018/091752
Publication Date:
December 26, 2019
Filing Date:
June 19, 2018
Export Citation:
Assignee:
SHANGHAI SPACE PEPTIDES PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K7/08; C07K1/04; C07K1/06
Foreign References:
| CN103242431A | 2013-08-14 | |||
| CN101033249A | 2007-09-12 | |||
| CN103319570A | 2013-09-25 | |||
| CN103374054A | 2013-10-30 | |||
| CN102532274A | 2012-07-04 |
Other References:
See also references of EP 3810627A4
Attorney, Agent or Firm:
SUNRAY INTELLECTUAL PROPERTY ATTORNEYS (CN)
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