Title:
SYNTHETIC METHOD OF ENANTIOMERICALLY PURE 2,2'-DIHYDROXY-1,1'-BINAPHTHYL-3-CARBOXYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2012/070896
Kind Code:
A3
Abstract:
The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 respectively are important intermediates for a process for preparing the respective compounds 2a and 2b of the following formula 2, which are 2,2'-binaphthol-3-aldehyde derivatives. The following compounds 2a and 2b are useful for preparing enantiomerically pure amino acids. The present invention provides a method for preparing the above compounds 1a and 1b very conveniently and economically, and suitably for mass production. [formula 2]
Inventors:
LEE HYUNIL (KR)
LEE YOUNG HEE (KR)
JUNG HEEJUNG (KR)
KOH YOUNG-KOOK (KR)
YOON HEUNGSIK (KR)
LEE YOUNG HEE (KR)
JUNG HEEJUNG (KR)
KOH YOUNG-KOOK (KR)
YOON HEUNGSIK (KR)
Application Number:
PCT/KR2011/009034
Publication Date:
July 19, 2012
Filing Date:
November 24, 2011
Export Citation:
Assignee:
AMINOLUX INC (KR)
LEE HYUNIL (KR)
LEE YOUNG HEE (KR)
JUNG HEEJUNG (KR)
KOH YOUNG-KOOK (KR)
YOON HEUNGSIK (KR)
LEE HYUNIL (KR)
LEE YOUNG HEE (KR)
JUNG HEEJUNG (KR)
KOH YOUNG-KOOK (KR)
YOON HEUNGSIK (KR)
International Classes:
C07C51/43; C07B57/00; C07C51/42; C07C63/36
Foreign References:
| KR20100039114A | 2010-04-15 |
Other References:
HOVORKA, M. ET AL.: "Chiral tridentate ligands based on 3-substituted binaphthols and derived complex hydrides of aluminum", PURE & APPL. CHEM. 0033-4545, vol. 70, no. 2, 1998, pages 415 - 418, XP008168693
FOGASSY, ELEMER ET AL.: "Optical resolution methods", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 4, 2006, pages 3011 - 3030, XP055109131
XIONG, XIAO-FENG ET AL.: "Merging Chiral Organocatalysts: Enantio- and Diastereoselective Direct Vinylogous Mannich Reaction of Alkylimines", CHEM. COMM., no. 45, 2009, pages 6994 - 6996, XP055109133
MOLNAR, PETER ET AL.: "Influence of Benzylamine on the Resolution of Ibuprofen with (+)-(R)-Phenylethylamine via Supercritical Fluid Extraction", CHIRALITY, vol. 21, no. 6, 2009, pages 628 - 636, XP055109134
See also references of EP 2643284A4
FOGASSY, ELEMER ET AL.: "Optical resolution methods", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 4, 2006, pages 3011 - 3030, XP055109131
XIONG, XIAO-FENG ET AL.: "Merging Chiral Organocatalysts: Enantio- and Diastereoselective Direct Vinylogous Mannich Reaction of Alkylimines", CHEM. COMM., no. 45, 2009, pages 6994 - 6996, XP055109133
MOLNAR, PETER ET AL.: "Influence of Benzylamine on the Resolution of Ibuprofen with (+)-(R)-Phenylethylamine via Supercritical Fluid Extraction", CHIRALITY, vol. 21, no. 6, 2009, pages 628 - 636, XP055109134
See also references of EP 2643284A4
Attorney, Agent or Firm:
KOREANA PATENT FIRM (Yeoksamdong 824-19, Kangnamku, Seoul 135-080, KR)
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