Title:
SYNTHETIC PEPTIDE FOR ADJUSTING BALANCE OF TYPE-1 TNF RECEPTORS AND TYPE-2 TNF RECEPTORS, AND USE OF SAID PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2014/046247
Kind Code:
A1
Abstract:
Provided is a method for adjusting the balance of TNF-R1 and TNF-R2 in cells present at a target organ, tissue or site. In the adjustment method provided by the present invention, (1) if raising the abundance of TNF-R2 present in a target cell in relation to that of TNF-R1, a synthetic peptide which is effectively constituted from a TNF-R1 signal peptide sequence or a modified amino acid sequence thereof is provided to said cell, or (2) if lowering the abundance of TNF-R2 present in said cell in relation to that of TNF-R1, a synthetic peptide which is effectively constituted from a TNF-R2 signal peptide sequence or a modified amino acid sequence thereof is provided to said cell.
Inventors:
KOBAYASHI NAHOKO (JP)
YOSHIDA TETSUHIKO (JP)
YOSHIDA TETSUHIKO (JP)
Application Number:
PCT/JP2013/075536
Publication Date:
March 27, 2014
Filing Date:
September 20, 2013
Export Citation:
Assignee:
TOAGOSEI CO LTD (JP)
International Classes:
A61K38/00; A61P25/28; A61P27/02; A61P43/00; C07K14/705; C12N5/079
Domestic Patent References:
| WO2012150676A1 | 2012-11-08 |
Other References:
AL-LAMKI RS ET AL.: "TNF receptors differentially signal and are differentially expressed and regulated in the human heart", AM J TRANSPLANT, vol. 9, no. 12, 2009, pages 2679 - 2696
NAKAZAWA T ET AL.: "Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment", INVEST OPHTHALMOL VIS SCI, vol. 52, no. 3, March 2011 (2011-03-01), pages 1384 - 1391
MARSCHINKE F ET AL.: "Dual effects of TNFalpha on nerve fiber formation from ventral mesencephalic organotypic tissue cultures", BRAIN RES, vol. 1215, 2008, pages 30 - 39
CHEN G ET AL.: "TNF-R1 signaling: a beautiful pathway", SCIENCE, vol. 296, 2002, pages 1634 - 1635
TARTAGLIA LA ET AL.: "The two different receptors for tumor necrosis factor mediate distinct cellular responses", PROC NATL ACAD SCI U S A, vol. 88, no. 20, 1991, pages 9292 - 9296
LUO D ET AL.: "Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis", AM J PATHOL, vol. 169, no. 5, 2006, pages 1886 - 1898
TAKEHIKO FURUSAWA ET AL.: "Kaishinjutsu Shujutsuki no Kecchu Cytokine Nodo (G-CSF, M-CSF, TNF-RI, TNF-R2) no Keijiteki Hendo", OFFICIAL PUBLICATION OF THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY, vol. 30, 2001, pages 325
MASAO SATO ET AL.: "Mansei Kansetsu Riumachi Kanja Hiza Kansetsueki ni Okeru TNFa to soluble TNF receptor(p55, p75) no Kento", RIUMACHI, vol. 41, no. 2, 2001, pages 426
KATSUHIKO NARUSE ET AL.: "Ninshin Chudokusho Ninpu ni Okeru TNF-R1 Oyobi R2 no Hatsugen ni Kansuru Kento", ACTA OBSTETRICA ET GYNAECOLOGIA JAPONICA, vol. 55, no. 2, 2003, pages 244
KUNIHIRO HOSONO ET AL.: "Daicho Senshu ni Okeru TNF-a, TNF-R1, TNF-R2 no Hatsugen Kaiseki", DAI 69 KAI, PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, 23 August 2010 (2010-08-23), pages 335
NAKAZAWA T ET AL.: "Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment", INVEST OPHTHALMOL VIS SCI, vol. 52, no. 3, March 2011 (2011-03-01), pages 1384 - 1391
MARSCHINKE F ET AL.: "Dual effects of TNFalpha on nerve fiber formation from ventral mesencephalic organotypic tissue cultures", BRAIN RES, vol. 1215, 2008, pages 30 - 39
CHEN G ET AL.: "TNF-R1 signaling: a beautiful pathway", SCIENCE, vol. 296, 2002, pages 1634 - 1635
TARTAGLIA LA ET AL.: "The two different receptors for tumor necrosis factor mediate distinct cellular responses", PROC NATL ACAD SCI U S A, vol. 88, no. 20, 1991, pages 9292 - 9296
LUO D ET AL.: "Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis", AM J PATHOL, vol. 169, no. 5, 2006, pages 1886 - 1898
TAKEHIKO FURUSAWA ET AL.: "Kaishinjutsu Shujutsuki no Kecchu Cytokine Nodo (G-CSF, M-CSF, TNF-RI, TNF-R2) no Keijiteki Hendo", OFFICIAL PUBLICATION OF THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY, vol. 30, 2001, pages 325
MASAO SATO ET AL.: "Mansei Kansetsu Riumachi Kanja Hiza Kansetsueki ni Okeru TNFa to soluble TNF receptor(p55, p75) no Kento", RIUMACHI, vol. 41, no. 2, 2001, pages 426
KATSUHIKO NARUSE ET AL.: "Ninshin Chudokusho Ninpu ni Okeru TNF-R1 Oyobi R2 no Hatsugen ni Kansuru Kento", ACTA OBSTETRICA ET GYNAECOLOGIA JAPONICA, vol. 55, no. 2, 2003, pages 244
KUNIHIRO HOSONO ET AL.: "Daicho Senshu ni Okeru TNF-a, TNF-R1, TNF-R2 no Hatsugen Kaiseki", DAI 69 KAI, PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, 23 August 2010 (2010-08-23), pages 335
Attorney, Agent or Firm:
ABE MAKOTO (JP)
Makoto Abe (JP)
Makoto Abe (JP)
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