Title:
SYNTHETIC PEPTIDES CAPABLE OF BINDING TO INFLUENZA HEMAGGLUTININ PROTEIN
Document Type and Number:
WIPO Patent Application WO/2013/121441
Kind Code:
A3
Abstract:
The invention provides peptides capable of binding with influenza hemagglutinin (HA) protein blocking pH-induced shape change or aggregation of the influenza hemagglutinin (HA) protein. The invention also provides a druggable site in influenza Hemagglutinin protein, said druggable site comprises peptide sequences comprising conserved residues.
Inventors:
FNU ASHISH (IN)
PANDEY KALPANA (IN)
RATHORE YOGENDRA SINGH (IN)
PANDEY KALPANA (IN)
RATHORE YOGENDRA SINGH (IN)
Application Number:
PCT/IN2013/000094
Publication Date:
October 10, 2013
Filing Date:
February 14, 2013
Export Citation:
Assignee:
COUNCIL SCIENT IND RES (IN)
International Classes:
C07K14/11; A61K39/145; C07K16/00; G01N23/201
Domestic Patent References:
| WO2010088393A2 | 2010-08-05 | |||
| WO2011094357A2 | 2011-08-04 | |||
| WO2009133249A1 | 2009-11-05 |
Foreign References:
| EP2003198A2 | 2008-12-17 | |||
| US20110150912A1 | 2011-06-23 | |||
| US6258527B1 | 2001-07-10 | |||
| EP2096121A1 | 2009-09-02 | |||
| US6337181B1 | 2002-01-08 | |||
| DE102005060920A1 | 2007-06-21 | |||
| US20090068221A1 | 2009-03-12 |
Other References:
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SUI JIANHUA ET AL: "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", vol. 16, no. 3, 1 March 2009 (2009-03-01), pages 265 - 273, XP002538005, ISSN: 1545-9993, Retrieved from the Internet [retrieved on 20090222], DOI: 10.1038/NSMB.1566
EKIERT DAMIAN C ET AL: "Antibody Recognition of a Highly Conserved Influenza Virus Epitope", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 324, no. 5924, 1 April 2009 (2009-04-01), pages 246 - 251, XP009144786, ISSN: 0036-8075
BULLOUGH P A ET AL: "Structure of influenza haemagglutinin at the pH of membrane fusion", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 371, no. 6492, 1 September 1994 (1994-09-01), pages 37 - 43, XP002361542, ISSN: 0028-0836, DOI: 10.1038/371037A0
RICHARD A. HOUGHTEN ET AL: "Effect of positional environmental domains on the variation of high-performance liquid chromatographic peptide retention coefficients", JOURNAL OF CHROMATOGRAPHY A, vol. 386, 1 January 1987 (1987-01-01), pages 223 - 228, XP055062803, ISSN: 0021-9673, DOI: 10.1016/S0021-9673(01)94599-6
J. M. WHITE: "Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin", THE JOURNAL OF CELL BIOLOGY, vol. 105, no. 6, 1 December 1987 (1987-12-01), pages 2887 - 2896, XP055072787, ISSN: 0021-9525, DOI: 10.1083/jcb.105.6.2887
MICHAL HAMMEL ET AL: "Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering.", JOURNAL OF MOLECULAR BIOLOGY, vol. 321, no. 1, 1 August 2002 (2002-08-01), pages 85 - 97, XP055072457, ISSN: 0022-2836
MERTENS H D T ET AL: "Structural characterization of proteins and complexes using small-angle X-ray solution scattering", JOURNAL OF STRUCTURAL BIOLOGY, ACADEMIC PRESS, UNITED STATES, vol. 172, no. 1, 1 October 2010 (2010-10-01), pages 128 - 141, XP027249564, ISSN: 1047-8477, [retrieved on 20100615]
SUI JIANHUA ET AL: "Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses", vol. 16, no. 3, 1 March 2009 (2009-03-01), pages 265 - 273, XP002538005, ISSN: 1545-9993, Retrieved from the Internet
EKIERT DAMIAN C ET AL: "Antibody Recognition of a Highly Conserved Influenza Virus Epitope", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 324, no. 5924, 1 April 2009 (2009-04-01), pages 246 - 251, XP009144786, ISSN: 0036-8075
BULLOUGH P A ET AL: "Structure of influenza haemagglutinin at the pH of membrane fusion", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 371, no. 6492, 1 September 1994 (1994-09-01), pages 37 - 43, XP002361542, ISSN: 0028-0836, DOI: 10.1038/371037A0
RICHARD A. HOUGHTEN ET AL: "Effect of positional environmental domains on the variation of high-performance liquid chromatographic peptide retention coefficients", JOURNAL OF CHROMATOGRAPHY A, vol. 386, 1 January 1987 (1987-01-01), pages 223 - 228, XP055062803, ISSN: 0021-9673, DOI: 10.1016/S0021-9673(01)94599-6
J. M. WHITE: "Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin", THE JOURNAL OF CELL BIOLOGY, vol. 105, no. 6, 1 December 1987 (1987-12-01), pages 2887 - 2896, XP055072787, ISSN: 0021-9525, DOI: 10.1083/jcb.105.6.2887
MICHAL HAMMEL ET AL: "Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering.", JOURNAL OF MOLECULAR BIOLOGY, vol. 321, no. 1, 1 August 2002 (2002-08-01), pages 85 - 97, XP055072457, ISSN: 0022-2836
MERTENS H D T ET AL: "Structural characterization of proteins and complexes using small-angle X-ray solution scattering", JOURNAL OF STRUCTURAL BIOLOGY, ACADEMIC PRESS, UNITED STATES, vol. 172, no. 1, 1 October 2010 (2010-10-01), pages 128 - 141, XP027249564, ISSN: 1047-8477, [retrieved on 20100615]
Attorney, Agent or Firm:
KUMARI, Jyoti et al. (Intellectual Property Attorneys109, Sector 4, Gurgaon National Capital Region 3, IN)
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