Title:
SYNTHETIC RECEPTOR FOR CONDITIONAL ACTIVATION OF IMMUNE CELLS
Document Type and Number:
WIPO Patent Application WO/2022/261346
Kind Code:
A8
Abstract:
Provided is a method of activating a recombinant immune cell expressing a synthetic receptor comprising an intracellular domain derived from killer cell immunoglobulin-like receptor 4 (KIR2DL4). Synthetic receptors described herein allow for the activation of recombinant immune cells against an antigen of interest without the deleterious effects of immune cell hyperactivation by existing CARs. The recombinant immune cells can thus be used to in the treatment of cancers or infectious diseases in subjects in need thereof, while limiting the hyperactivation of an immune response associated with traditional recombinant cell-based therapies.
Inventors:
JACKO MARTIN (US)
GOEBEL AARON (US)
FARLOW JUSTIN (US)
VARGAS-INCHAUSTEGUI DIEGO A (US)
GOFMAN YANA (US)
GOEBEL AARON (US)
FARLOW JUSTIN (US)
VARGAS-INCHAUSTEGUI DIEGO A (US)
GOFMAN YANA (US)
Application Number:
PCT/US2022/032865
Publication Date:
February 29, 2024
Filing Date:
June 09, 2022
Export Citation:
Assignee:
SEROTINY INC (US)
International Classes:
C12N15/62; A61K35/17; A61P35/00; C07K14/705; A61K39/00
Attorney, Agent or Firm:
SHUSTER, Michael J. et al. (US)
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