Title:
SYNTHETIC TECHNIQUES AND INTERMEDIATES FOR POLYHYDROXY DIENYL LACTONES AND MIMICS THEREOF
Document Type and Number:
WIPO Patent Application WO2005079378
Kind Code:
A3
Abstract:
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
Inventors:
SMITH AMOS B III (US)
QUI YUPING (US)
KAUFMAN MICHAEL (US)
ARIMOTO HIROKAZU (JP)
JONES DAVID R (US)
KOBAYASHI KAORU (JP)
BEAUCHAMP THOMAS J (US)
QUI YUPING (US)
KAUFMAN MICHAEL (US)
ARIMOTO HIROKAZU (JP)
JONES DAVID R (US)
KOBAYASHI KAORU (JP)
BEAUCHAMP THOMAS J (US)
Application Number:
PCT/US2005/004643
Publication Date:
February 16, 2006
Filing Date:
February 11, 2005
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
SMITH AMOS B III (US)
QUI YUPING (US)
KAUFMAN MICHAEL (US)
ARIMOTO HIROKAZU (JP)
JONES DAVID R (US)
KOBAYASHI KAORU (JP)
BEAUCHAMP THOMAS J (US)
SMITH AMOS B III (US)
QUI YUPING (US)
KAUFMAN MICHAEL (US)
ARIMOTO HIROKAZU (JP)
JONES DAVID R (US)
KOBAYASHI KAORU (JP)
BEAUCHAMP THOMAS J (US)
International Classes:
C07C271/12; C07D213/30; C07D263/22; C07D303/16; C07D309/10; C07D309/30; C07D309/32; C07D319/06; C07D339/08; C07D407/06; C07D413/06; C07D413/12; C07D417/06; C07F7/18; C07F9/54; (IPC1-7): C07F7/18; C07D309/30
Other References:
PATERSON I. AND WREN S.P.: "Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1-C8 lactone subunit", J. CHEM. SOC. CHEM. COMMUN., 1993, pages 1790 - 1792, XP001028939
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