Title:
SYNTHETIC TRITERPENOIDS AND METHODS FOR MODULATING STEM/PROGENITOR CELL GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2013/169740
Kind Code:
A3
Abstract:
Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods for producing a cell, such as a stem or progenitor cell, with induced gene expression by contacting a stem or progenitor cell with an effective amount of a synthetic triterpenoid to induce the expression of one or more of SOX9 (Sex determining region Y-box 9), COL2A1 (Type II Collagen (alphal )), TGF-βΙ, TGF-p2, TGF-33, BMP2, BMP4, BMPRII (Bone Morphogenic Protein Receptor II), SMAD (Small Mothers Against Decapentaplegic) 3, SMAD4, SMAD6, SMAD7, TIMP (Tissue Inhibitor of Metalloproteinase)-1 or TIMP-2 in the stem or progenitor cell, wherein the stem or progenitor cell is not a mesenchymal stem cell, periosteium cell or osteoprogenitor cell. In one embodiment, the stem or progenitor cell is multipotent.
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Inventors:
GRIBBLE GORDON W (US)
FU LIANGFENG (US)
SPORN MICHAEL B (US)
LIBY KAREN T (US)
FU LIANGFENG (US)
SPORN MICHAEL B (US)
LIBY KAREN T (US)
Application Number:
PCT/US2013/039902
Publication Date:
February 27, 2014
Filing Date:
May 07, 2013
Export Citation:
Assignee:
DARTMOUTH COLLEGE (US)
International Classes:
A61K31/56
Foreign References:
| US20090060873A1 | 2009-03-05 | |||
| US20100056777A1 | 2010-03-04 |
Other References:
BENSASSON ET AL.: "Efficacy ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.", CHEM BIOL INTERACT., vol. 186, no. 2, 2010, pages 118 - 126, Retrieved from the Internet [retrieved on 20131203]
HONDA ET AL.: "Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages.", J. MED. CHEM., vol. 3, no. 22, 2000, pages 4233 - 4246
HONDA ET AL.: "Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages.", J. MED. CHEM., vol. 3, no. 22, 2000, pages 4233 - 4246
Attorney, Agent or Firm:
TYRRELL, Katheleen, A. et al. (66 E. Main StreetMarlton, NJ, US)
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