SYSTEM FOR EVALUATING DRUG METABOLISM CAPACITY AND METHOD OF USING THE SAME

Title:

SYSTEM FOR EVALUATING DRUG METABOLISM CAPACITY AND METHOD OF USING THE SAME

Document Type and Number:

WIPO Patent Application WO/2004/078968

Kind Code:

A1

Abstract:

The amount of a drug consumed by a specific drug metabolic enzyme and/or the amount of its metabolite are measured by using a packing agent the surface of which is coated with a polymer showing a change in hydration force within a temperature range of from 0 to 80°C and controlling the temperature by using a chromatography having an aqueous mobile phase. According to this system, drug metabolism capacity can be exactly evaluated by a convenient procedure without undesirably affecting the environment.

Inventors:

KANAZAWA HIDEKO (JP)
OKANO TERUO (JP)

Application Number:

PCT/JP2004/002753

Publication Date:

September 16, 2004

Filing Date:

March 04, 2004

Export Citation:

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Assignee:

KANAZAWA HIDEKO (JP)
OKANO TERUO (JP)

International Classes:

G01N33/573; G01N33/574; G01N33/68; (IPC1-7): C12N15/09; C12Q1/00; C12Q1/68; G01N33/50; G01N33/53

Domestic Patent References:

WO2002052044A2	2002-07-04
WO2001009198A1	2001-02-08

Foreign References:

JP2002020318A	2002-01-23
EP1081492A1	2001-03-07
JPH02211865A	1990-08-23

Other References:

LANGE R. ET AL: "Interaction of tryptophan residues of cytochrome P450scc with a highly specific fluorescence quencher, a substrate analogue, compared to acrylamide and iodide", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 226, no. 3, 1994, pages 963 - 970, XP002979960
ANAL. CHEM., vol. 69, 1997, pages 823 - 830
See also references of EP 1607479A4

Attorney, Agent or Firm:

Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo04, JP)

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