Title:
SYSTEM AND METHOD FOR ASSESSING THE RISK OF COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2021/028846
Kind Code:
A3
Abstract:
Colorectal cancer is a severe disease, if not assessed properly, it may lead to the death of an individual. A system and method for assessing the risk of colorectal cancer has been provided. The system is configured to assess individuals to check the risk of presence of colorectal cancer (CRC) and/or adenomatous (colonic/ rectal) polyps, by quantifying the abundance of sensory proteins in their gut microbiome. The system further categorizes the person into one of healthy, adenoma and cancerous categories based on the nature and abundance of sensory proteins in the gut microbiome. The system further describes microbiota based therapeutics for treatment of the person with colorectal adenoma and/or cancer through administration of at least one of a consortium of healthy microbes, antibiotic drugs and pre-/ pro-/ syn-/ post-biotic compounds or fecal microbiome transplant which could modulate the disease microbiome composition towards a healthy equilibrium.
Inventors:
MANDE SHARMILA SHEKHAR (IN)
BOSE TUNGADRI (IN)
BHAR SUBHRAJIT (IN)
DUTTA ANIRBAN (IN)
SINGH RASHMI (IN)
BOSE TUNGADRI (IN)
BHAR SUBHRAJIT (IN)
DUTTA ANIRBAN (IN)
SINGH RASHMI (IN)
Application Number:
PCT/IB2020/057585
Publication Date:
April 22, 2021
Filing Date:
August 12, 2020
Export Citation:
Assignee:
TATA CONSULTANCY SERVICES LTD (IN)
International Classes:
A61K31/437; A61K36/06; C12Q1/68; G01N33/569
Foreign References:
| US20140179726A1 | 2014-06-26 | |||
| US20160090578A1 | 2016-03-31 | |||
| US20100297187A1 | 2010-11-25 | |||
| US20180258495A1 | 2018-09-13 |
Other References:
XIAO QIAN, LU WEI, KONG XIANGXING, SHAO YANG W., HU YETING, WANG AO, BAO HUA, LIU KAIHUA, WANG XIAONAN, WU XUE, ZHENG SHU, YUAN YI: "Circulating bacterial DNA as a tool towards non-invasive biomarkers for colorectal cancer and adenoma", BIORXIV, 23 May 2019 (2019-05-23), pages 1 - 30, XP055817471
Attorney, Agent or Firm:
KHAITAN & CO (IN)
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