Title:
SYSTEM AND METHOD FOR DELIVERING PROTEASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2014/124029
Kind Code:
A3
Abstract:
The disclosed invention provides a system and method of artificially retarding fibrin- based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid ("TA"). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation. Next, the formulation along with fibrinogen and thrombin is applied to a wound site where an outer surface of the polymer microsphere degrades in a proteolytic environment to expose and release the incorporated protease inhibitor to the surrounding hydrogel or sealant or clot matrix at the wound site.
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Inventors:
BORDOLOI BINOY (US)
SARMA NAYAN (US)
EISENBERG RODNEY (US)
SARMA NAYAN (US)
EISENBERG RODNEY (US)
Application Number:
PCT/US2014/014906
Publication Date:
March 05, 2015
Filing Date:
February 05, 2014
Export Citation:
Assignee:
BORDOLOI BIOTECH LLC (US)
International Classes:
A61K9/50; A61K9/14; A61K9/52; A61K35/55
Domestic Patent References:
| WO2012020412A2 | 2012-02-16 |
Foreign References:
| US6444791B1 | 2002-09-03 | |||
| US8273795B2 | 2012-09-25 | |||
| US20110021964A1 | 2011-01-27 | |||
| US6113948A | 2000-09-05 | |||
| US6627785B1 | 2003-09-30 | |||
| US5506264A | 1996-04-09 |
Other References:
SAMMARTINO, G ET AL.: "Local Delivery Of The Hemostatic Agent Tranexamic Acid In Chronically Anticoagulated Patients.", THE JOURNAL OF CRANIOFACIAL SURGERY., vol. 23, November 2012 (2012-11-01), pages E648 - E652
MORITERA, T ET AL.: "Microspheres Of Biodegradable Polymers As A Drug-Delivery System In The Vitreous.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 32, May 1991 (1991-05-01), pages 1785 - 1790
ARTISS-FIBRINOGEN HUMAN THROMBIN HUMAN, 2011, Retrieved from the Internet [retrieved on 20140513]
CEGNAR, M ET AL.: "Poly(lactide-co-glycolide) Nanoparticles As A Carrier System For Delivering Cysteine Protease Inhibitor Cystatin Into Tumor Cells.", EXPERIMENTAL CELL RESEARCH., vol. 301, 2004, pages 223 - 231
MORITERA, T ET AL.: "Microspheres Of Biodegradable Polymers As A Drug-Delivery System In The Vitreous.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 32, May 1991 (1991-05-01), pages 1785 - 1790
ARTISS-FIBRINOGEN HUMAN THROMBIN HUMAN, 2011, Retrieved from the Internet
CEGNAR, M ET AL.: "Poly(lactide-co-glycolide) Nanoparticles As A Carrier System For Delivering Cysteine Protease Inhibitor Cystatin Into Tumor Cells.", EXPERIMENTAL CELL RESEARCH., vol. 301, 2004, pages 223 - 231
Attorney, Agent or Firm:
CHERSKOV, Michael (LLC123 W. Madison St.,Suite 40, Chicago Illinois, US)
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