Title:
SYSTEM AND METHOD FOR DETECTING AND IDENTIFYING MOLECULAR EVENTS IN A TEST SAMPLE
Document Type and Number:
WIPO Patent Application WO2001027610
Kind Code:
A3
Abstract:
A molecular detection system for detecting the presence or absence of a molecular event within a test sample includes a fluid reservoir, a signal source, a measurement probe, and a signal detector. The measurement probe includes a probe head and a connecting end. The probe head is configured to electromagnetically couple an incident test signal to the test sample within the detection region of the fluid reservoir. The interaction of the incident test signal with the test sample produces a modulated test signal, at least a portion of which the probe head is configured to recover. The system further includes a signal detector that is coupled to the connecting end of the measurement probe and configured to recover the modulated test signal.
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Inventors:
CHAPMAN ROBERT G
HEFTI JOHN J
BARTELL BARRETT J
RHODES MARK A
ZHAO MIN
HEFTI JOHN J
BARTELL BARRETT J
RHODES MARK A
ZHAO MIN
Application Number:
PCT/US2000/028491
Publication Date:
March 28, 2002
Filing Date:
October 13, 2000
Export Citation:
Assignee:
SIGNATURE BIOSCIENCE INC (US)
International Classes:
B01L3/00; G01N35/08; G01N22/00; G01N37/00; (IPC1-7): G01N22/00; G01N33/543
Domestic Patent References:
| WO1998039639A1 | 1998-09-11 | |||
| WO1999039190A1 | 1999-08-05 | |||
| WO1995003542A1 | 1995-02-02 |
Foreign References:
| EP0519250A2 | 1992-12-23 |
Other References:
FOLGERO K ET AL: "PERMITTIVITY MEASUREMENT OF THIN LIQUID LAYERS USING OPEN-ENDED COAXIAL PROBES", MEASUREMENT SCIENCE AND TECHNOLOGY,GB,IOP PUBLISHING, BRISTOL, vol. 7, no. 8, 1 August 1996 (1996-08-01), pages 1164 - 1173, XP000631806, ISSN: 0957-0233
DUHAMEL F ET AL: "MEASUREMENTS OF COMPLEX PERMITTIVITY OF BIOLOGICAL AND ORGANIC LIQUIDS UP TO 110 GHZ", IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST,US,NEW YORK, NY: IEEE, 8 June 1997 (1997-06-08), pages 107 - 110, XP000767171, ISBN: 0-7803-3815-4
HEFTI J ET AL: "SENSITIVE DETECTION METHOD OF DIELECTRIC DISPERSIONS IN AQUEOUS-BASED, SURFACE-BOUND MACROMOLECULAR STRUCTURES USING MICROWAVE SPECTROSCOPY", APPLIED PHYSICS LETTERS,AMERICAN INSTITUTE OF PHYSICS. NEW YORK,US, vol. 75, no. 12, 20 September 1999 (1999-09-20), pages 1802 - 1804, XP000868333, ISSN: 0003-6951
DUHAMEL F ET AL: "MEASUREMENTS OF COMPLEX PERMITTIVITY OF BIOLOGICAL AND ORGANIC LIQUIDS UP TO 110 GHZ", IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST,US,NEW YORK, NY: IEEE, 8 June 1997 (1997-06-08), pages 107 - 110, XP000767171, ISBN: 0-7803-3815-4
HEFTI J ET AL: "SENSITIVE DETECTION METHOD OF DIELECTRIC DISPERSIONS IN AQUEOUS-BASED, SURFACE-BOUND MACROMOLECULAR STRUCTURES USING MICROWAVE SPECTROSCOPY", APPLIED PHYSICS LETTERS,AMERICAN INSTITUTE OF PHYSICS. NEW YORK,US, vol. 75, no. 12, 20 September 1999 (1999-09-20), pages 1802 - 1804, XP000868333, ISSN: 0003-6951
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