Title:
SYSTEM AND METHOD FOR EXPRESSION PROTEOMICS BASED ON ISOTOPE RATIO MODIFICATION
Document Type and Number:
WIPO Patent Application WO2005069891
Kind Code:
A3
Abstract:
The present invention relates to modification of isotope ratios in peptides and polypeptides as an alternative to full isotopic exchange for coding in proteomics. Subtle modification of isotope ratio does not compromise protein identification experiments and can thus provide elemental composition data for accurate isotope ratio decoding. Application of subtle modification of isotope ratio proteomics (SMIRP) offers a convenient approach to in vivo isotope coding.
Inventors:
WHITELEGGE JULIAN P (US)
AGUS DAVID B (US)
KATZ JONATHAN (US)
AGUS DAVID B (US)
KATZ JONATHAN (US)
Application Number:
PCT/US2005/001393
Publication Date:
January 26, 2006
Filing Date:
January 13, 2005
Export Citation:
Assignee:
CEDARS SINAI MEDICAL CENTER (US)
WHITELEGGE JULIAN P (US)
AGUS DAVID B (US)
KATZ JONATHAN (US)
WHITELEGGE JULIAN P (US)
AGUS DAVID B (US)
KATZ JONATHAN (US)
International Classes:
G01N33/68; (IPC1-7): A61K51/00; A61B5/055; C07C331/16
Foreign References:
| US6670194B1 | 2003-12-30 | |||
| US20030153729A1 | 2003-08-14 |
Other References:
See also references of EP 1708758A4
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