Title:
SYSTEM AND METHOD FOR PROVIDING NEOANTIGEN IMMUNOTHERAPY INFORMATION BY USING ARTIFICIAL-INTELLIGENCE-MODEL-BASED MOLECULAR DYNAMICS BIG DATA
Document Type and Number:
WIPO Patent Application WO/2020/185010
Kind Code:
A1
Abstract:
The present invention relates to a system and method for predicting, based on molecular dynamics, a neoantigen and immune response induction, in which, by producing a neoantigen candidate group through genomic mutations, and then predicting MHC-antigen binding affinity for neoantigen candidates through molecular dynamics, the induction of immunity against a neoantigen with high binding potential can be verified. The present invention provides a method for providing neoantigen immunotherapy information for discovering a neoantigen by using AI-based molecular dynamics big data, the method comprising the steps of: (A) producing a neoantigen candidate group through genomic mutations; (B) filtering specificity of the neoantigen candidate group by tissues and diseases; (C) predicting in silico binding between a neoantigen and MHC; and (D) calculating and ranking TCR activities. According to such a present invention, precision medical technology combined with AI deep learning using big data of the present invention can contribute to medical industrialization of a specific neoantigen prediction technique customized for patients.
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Inventors:
JUNG JONGSUN (KR)
HONG JONGHUI (KR)
HONG JONGHUI (KR)
Application Number:
PCT/KR2020/003464
Publication Date:
September 17, 2020
Filing Date:
March 12, 2020
Export Citation:
Assignee:
SYNTEKABIO INC (KR)
International Classes:
G16B20/20; C40B30/04; G01N33/68; G16B5/00; G16B40/00
Domestic Patent References:
| WO2018136664A1 | 2018-07-26 | |||
| WO2018195357A1 | 2018-10-25 |
Foreign References:
| KR20130119845A | 2013-11-01 |
Other References:
TRIVANOVIĆ DRENKA, KRSTIĆ JELENA, DJORDJEVIĆ IVANA OKIĆ, MOJSILOVIĆ SLAVKO, SANTIBANEZ JUAN FRANCISCO, BUGARSKI DIANA, JAUKOVIĆ AL: "The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation", MEDIATORS OF INFLAMMATION, vol. 2016, 2016, pages 1 - 14, XP055739604
HUTCHISON, S. ET AL.: "Identifying neoantigens for use in immunotherapy", MAMMALIAN GENOME, vol. 29, 2018, pages 714 - 730, XP036644504, DOI: 10.1007/s00335-018-9771-6
HUTCHISON, S. ET AL.: "Identifying neoantigens for use in immunotherapy", MAMMALIAN GENOME, vol. 29, 2018, pages 714 - 730, XP036644504, DOI: 10.1007/s00335-018-9771-6
Attorney, Agent or Firm:
KWON, Hyung-Seok (KR)
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