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Title:
SYSTEM AND METHODS FOR ELECTROKINETIC LOADING OF SUB-MICRON-SCALE REACTION CHAMBERS
Document Type and Number:
WIPO Patent Application WO/2019/136202
Kind Code:
A3
Abstract:
Apparatus and techniques for electrokinetic loading of samples of interest into sub- micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.

Inventors:
ROTHBERG, Jonathan, M. (215 Uncas Point Road, Guilford, CT, 06437, US)
CHEN, Guojun (115 Maple Street, Sherborn, MA, 01770, US)
LACKEY, Jeremy (636 Nortontown Road, Guilford, CT, 06437, US)
GORYAYNOV, Alexander (155 Bradley Street, Apt. 2New Haven, CT, 06511, US)
SCHMID, Gerard (140 Wildrose Avenue, Guilford, CT, 06437, US)
KABIRI, Ali (58 Green Hill Road, Madison, CT, 06443, US)
REARICK, Todd (5 Wyndemere Court, Cheshire, CT, 06410, US)
SCHULTZ, Jonathan, C. (121 Landon's Way, Guilford, CT, 06437, US)
GHASEMI, Farshid (1120 Village Walk, Guilford, CT, 06437, US)
FIFE, Keith, G. (635 Matadero Avenue, Palo Alto, CA, 94306, US)
Application Number:
US2019/012271
Publication Date:
November 07, 2019
Filing Date:
January 04, 2019
Export Citation:
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Assignee:
QUANTUM-SI INCORPORATED (530 Old Whitfield Street, Guilford, CT, 06437, US)
International Classes:
B01L3/00
Foreign References:
US20150072868A12015-03-12
US20110223590A12011-09-15
Attorney, Agent or Firm:
PRITZKER, Randy, J. et al. (Wolf, Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, 02210-2206, US)
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