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Title:
THE TWEAK/FN14 SYSTEM REGULATES SKELETAL MUSCLE ATROPHY AND REGENERATION
Document Type and Number:
WIPO Patent Application WO/2011/097500
Kind Code:
A3
Abstract:
The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.

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Inventors:
KUMAR ASHOK (US)
Application Number:
PCT/US2011/023774
Publication Date:
December 29, 2011
Filing Date:
February 04, 2011
Export Citation:
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Assignee:
UNIV LOUISVILLE RES FOUND (US)
KUMAR ASHOK (US)
International Classes:
A61K39/395; A61P3/10; A61P21/00; A61P35/00; C07K16/28
Foreign References:
EP1566636A12005-08-24
US20060127397A12006-06-15
US20060240004A12006-10-26
US20080279853A12008-11-13
Other References:
CHARU DOGRA ET AL.: "TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine", THE FASEB JOURNAL, vol. 21, no. 8, 2007, pages 1857 - 1869
A. X. BIGARD ET AL.: "Muscle unloading induces slow to fast transitions in myofibrillar but not mitochondrial properties. Relevance to skeletal muscle abnormalities in heart failure", J. MOL. CELL CARDIOL., vol. 30, no. 11, 1998, pages 2391 - 2401
MAHASWETA GIRGENRATH ET AL.: "TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration", THE EMBO JOURNAL, vol. 25, no. 24, 2006, pages 5826 - 5839
Attorney, Agent or Firm:
MALEN, Peter L. et al. (St. Paul, MN, US)
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