Title:
SYSTEMIC DELIVERY OF POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO/2018/209358
Kind Code:
A3
Abstract:
A method of delivering a recombinant virus to a skin tissue is provided. The method includes applying ultrasound to the skin tissue, and administering the recombinant virus to the skin tissue.
Inventors:
MILANOVA DENITSA M (US)
CHURCH GEORGE M (US)
DAVIDSOHN NOAH (US)
SCHOELLHAMMER CARL (US)
LANGER ROBERT S (US)
MANDINOVA ANNA I (US)
TRAVERSO CARLO GIOVANNI (US)
LI LI (US)
CHURCH GEORGE M (US)
DAVIDSOHN NOAH (US)
SCHOELLHAMMER CARL (US)
LANGER ROBERT S (US)
MANDINOVA ANNA I (US)
TRAVERSO CARLO GIOVANNI (US)
LI LI (US)
Application Number:
PCT/US2018/032597
Publication Date:
December 06, 2018
Filing Date:
May 14, 2018
Export Citation:
Assignee:
HARVARD COLLEGE (US)
International Classes:
A61K31/7088; A61K48/00; A61N7/00; A61P17/00; A61Q19/08; C12N15/86; C12N15/864
Foreign References:
| US20100217212A1 | 2010-08-26 | |||
| US20060084938A1 | 2006-04-20 | |||
| US20080119433A1 | 2008-05-22 |
Other References:
DELALANDE. A. ET AL.: "Ultrasound And Microbubble-Assisted Gene Delivery: Recent Advances A nd Ongoing Challenges", THERAPEUTIC DELIVERY, vol. 3, no. 10, 23 October 2012 (2012-10-23), pages 1199 - 1215
DATABASE Nucleotide [O] 26 June 2008 (2008-06-26), "Homo Sapiens Collagen, Type III, Alpha 1, mRNA (cDNA Clone MGC: 39848 IMAGE:5405119), Complete Cds", XP055553545, retrieved from ncbi Database accession no. BC028178.1
DATABASE GENBANK [O] 2 September 2016 (2016-09-02), "Synthetic construct Mus musculus collagen, type I, alpha 1, mRNA (cDNA clone IMAGE:4036918), **** WARNING: chimeric clone ****", XP055553549, retrieved from ncbi Database accession no. BC042642.1
DATABASE Nucleotide [O] 26 June 2008 (2008-06-26), "Homo Sapiens Collagen, Type III, Alpha 1, mRNA (cDNA Clone MGC: 39848 IMAGE:5405119), Complete Cds", XP055553545, retrieved from ncbi Database accession no. BC028178.1
DATABASE GENBANK [O] 2 September 2016 (2016-09-02), "Synthetic construct Mus musculus collagen, type I, alpha 1, mRNA (cDNA clone IMAGE:4036918), **** WARNING: chimeric clone ****", XP055553549, retrieved from ncbi Database accession no. BC042642.1
Attorney, Agent or Firm:
WU, Pei (US)
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