SYSTEMS, COMPOSITIONS, AND METHODS FOR TRANSPLANTATION AND TREATING CONDITIONS

WIPO Patent Application WO/2015/031654

A3

Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds.

JP2005281189	REGULATOR FOR HARD TISSUE FORMATION AND CHONDROGENESIS, PATHOLOGIC CALCIFICATION INHIBITOR, FUNCTIONAL FOOD, GENETICALLY TREATING MEDICINE, SCREENING METHOD, AND METHOD FOR MEASURING CALCIFICATION
WO/2003/038034	CALCITONIN-LIKE SEQUENCE EXPRESSED BY GONADOTROPES OF THE ANTERIOR PITUITARY
WO/2004/019904	BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING ALLERGIES OR ASTHMA

HANNA LEWIS (US)
LAUGHLIN JOHN DAVID (US)
BROWNING SHAWN ROBERT (US)

PCT/US2014/053223

November 05, 2015

August 28, 2014

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CYTONICS CORP (US)

A61K38/00

US20090123452A1	2009-05-14
US20060165710A1	2006-07-27
US20100098684A1	2010-04-22
US5563120A	1996-10-08

BINDER, R.: "Purification of alpha2-macroglobulin and the construction of immunogenic alpha2-macroglobulin-peptide complexes for use as cancer vaccines", METHODS, vol. 32, no. Iss. 1, 1 January 2004 (2004-01-01), pages 29 - 31, XP004473399

McANDREW, Christopher et al. (Wilson Sonsini Goodrich & Rosati650 Page Mill Roa, Palo Alto CA, US)

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