SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING

Title:

SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING

Document Type and Number:

WIPO Patent Application WO2005013090

Kind Code:

A3

Abstract:

Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.

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Inventors:

GUSTAFSSON CLAES (US)
GOVINDARAJAN SRIDHAR (US)
MINSHULL JEREMY STEPHEN (US)

Application Number:

PCT/US2004/024752

Publication Date:

April 13, 2006

Filing Date:

July 30, 2004

Export Citation:

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Assignee:

DNA TWOPOINTO INC (US)
GUSTAFSSON CLAES (US)
GOVINDARAJAN SRIDHAR (US)
MINSHULL JEREMY STEPHEN (US)

International Classes:

G16B20/20; C07K16/10; C07K16/46; G16B15/20; G16B20/50; G16B40/30; G01N; G06F; (IPC1-7): G01N33/00; G01N33/48

Foreign References:

US20020177170A1	2002-11-28
US20020119492A1	2002-08-29

Other References:

SCHNEIDER G. ET AL: "Peptide design by artificial neural networks and computer-based evolutionary search", BIOCHEMISTRY, vol. 95, no. 21, 13 October 1998 (1998-10-13), pages 12179 - 12184, XP002127398

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