Title:
SYSTEMS AND METHODS FOR DETERMINING T-CELL CROSS-REACTIVITY BETWEEN ANTIGENS
Document Type and Number:
WIPO Patent Application WO/2023/146978
Kind Code:
A3
Abstract:
A neoantigen model discrimination method to determine if the immune system can discriminate it from "self" by estimating if a neoantigen has sufficient antigenic distance from its wild-type peptide to differentially bind the MHC or activate a T cell. In one embodiment, a model can be integrated to estimate the fitness of tumor clones as the aggregate of the cost due to T cells recognizing high quality neoantigens offset by the gain from mutations in canonical oncogenes. In an additional embodiment, a model can be used to rationally identify antigens that either elicit desired, or prevent undesired responses of any immunologically based medicine.
Inventors:
BALACHANDRAN VINOD (US)
SETHNA ZACHARY (US)
ROJAS LUIS (US)
GREENBAUM BENJAMIN D (US)
SETHNA ZACHARY (US)
ROJAS LUIS (US)
GREENBAUM BENJAMIN D (US)
Application Number:
PCT/US2023/011643
Publication Date:
September 07, 2023
Filing Date:
January 26, 2023
Export Citation:
Assignee:
MEMORIAL SLOAN KETTERING CANCER CENTER (US)
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (US)
SLOAN KETTERING INST CANCER RES (US)
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (US)
SLOAN KETTERING INST CANCER RES (US)
International Classes:
C12Q1/6886; A61P35/00; G16B20/20; G16B30/20; A61K39/395; C12Q1/6881
Domestic Patent References:
| WO2020181240A1 | 2020-09-10 |
Foreign References:
| US20200232040A1 | 2020-07-23 | |||
| US20200362418A1 | 2020-11-19 | |||
| US20190263910A1 | 2019-08-29 |
Attorney, Agent or Firm:
FERNANDES, Jolene S. et al. (US)
Download PDF: