Title:
SYSTEMS, METHODS AND DEVICES FOR MEASURING GROWTH/ONCOGENIC & MIGRATION/METASTATIC POTENTIAL
Document Type and Number:
WIPO Patent Application WO/2012/048269
Kind Code:
A3
Abstract:
Systems, methods, and devices for determining various properties of cells are provided herein. In one aspect, the method includes measuring one or more variables based on physical and/or chemical characteristics of a cell or its environment. The method further includes calculating one or more quantifiable metrics based on a mathematical expression including one or more of the variables, where those metrics correlate with at least one of the growth characteristics of the cell, the motility characteristics of the cell, the oncogenic potential of the cell, or the metastatic potential of the cell. Various aspects of systems and devices for determining various properties of cells are also provided herein.
More Like This:
| WO/1997/021347 | CELL CULTURE APPARATUS AND METHOD |
| JP2004532896 | Diagnosis and treatment of type I diabetes |
Inventors:
CHANDER ASHOK C (US)
Application Number:
PCT/US2011/055444
Publication Date:
July 25, 2013
Filing Date:
October 07, 2011
Export Citation:
Assignee:
CHANDER ASHOK C (US)
International Classes:
C12N5/00; G01N33/50
Domestic Patent References:
| WO2009032164A1 | 2009-03-12 | |||
| WO2009005770A1 | 2009-01-08 |
Foreign References:
| US20050244843A1 | 2005-11-03 | |||
| US7160687B1 | 2007-01-09 | |||
| US20060270032A1 | 2006-11-30 |
Other References:
YING MEI ET AL: "Gradient substrate assembly for quantifying cellular response to biomaterials", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 79A, no. 4, 15 December 2006 (2006-12-15), pages 974 - 988, XP055057767, ISSN: 1549-3296, DOI: 10.1002/jbm.a.30883
LO CHUN-MIN ET AL: "Cell movement is guided by the rigidity of the substrate", BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, US, vol. 79, no. 1, 1 July 2000 (2000-07-01), pages 144 - 152, XP002502429, ISSN: 0006-3495, DOI: 10.1016/S0006-3495(00)76279-5
CAI K ET AL: "Regulation of endothelial cells migration on poly(d, l-lactic acid) films immobilized with collagen gradients", COLLOIDS AND SURFACES. B, BIOINTERFACES, ELSEVIER, AMSTERDAM, NL, vol. 79, no. 1, 1 August 2010 (2010-08-01), pages 291 - 297, XP027053845, ISSN: 0927-7765, [retrieved on 20100421]
ALBINI A: "Tumor and endothelial cell invasion of basement membranes. The matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms", PATHOLOGY ONCOLOGY RESEARCH, TUD. KIADO, BUDAPEST, HU, vol. 4, no. 3, 1 January 1998 (1998-01-01), pages 230 - 241, XP002340084, ISSN: 1219-4956
LO CHUN-MIN ET AL: "Cell movement is guided by the rigidity of the substrate", BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, US, vol. 79, no. 1, 1 July 2000 (2000-07-01), pages 144 - 152, XP002502429, ISSN: 0006-3495, DOI: 10.1016/S0006-3495(00)76279-5
CAI K ET AL: "Regulation of endothelial cells migration on poly(d, l-lactic acid) films immobilized with collagen gradients", COLLOIDS AND SURFACES. B, BIOINTERFACES, ELSEVIER, AMSTERDAM, NL, vol. 79, no. 1, 1 August 2010 (2010-08-01), pages 291 - 297, XP027053845, ISSN: 0927-7765, [retrieved on 20100421]
ALBINI A: "Tumor and endothelial cell invasion of basement membranes. The matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms", PATHOLOGY ONCOLOGY RESEARCH, TUD. KIADO, BUDAPEST, HU, vol. 4, no. 3, 1 January 1998 (1998-01-01), pages 230 - 241, XP002340084, ISSN: 1219-4956
Attorney, Agent or Firm:
MOLLAGHAABABA, Reza et al. (19th Floor High Street Tower,125 High Stree, Boston MA, US)
Download PDF: